Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview.
In: ISSN: 1201-9712, 2016
Online
academicJournal
Zugriff:
International audience ; Objectives: Neisseria meningitidis is the major cause of seasonal meningitis epidemics in the African meningitis belt. In the changing context of a reduction in incidence of serogroup A and an increase in incidence of serogroups W and C and of Streptococcus pneumoniae, a better understanding of the determinants driving the disease transmission dynamics remains crucial to improving bacterial meningitis control.Methods: The literature was searched to provide a multi-disciplinary overview of the determinants of meningitis transmission dynamics in the African meningitis belt.Results: Seasonal hyperendemicity is likely predominantly caused by increased invasion rates, sporadic localized epidemics by increased transmission rates, and larger pluri-annual epidemic waves by changing population immunity. Carriage likely involves competition for colonization and cross-immunity. The duration of immunity likely depends on the acquisition type. Major risk factors include dust and low humidity, and presumably human contact rates and co-infections; social studies highlighted environmental and dietary factors, with supernatural explanations.Conclusions: Efforts should focus on implementing multi-country, longitudinal seroprevalence and epidemiological studies, validating immune markers of protection, and improving surveillance, including more systematic molecular characterizations of the bacteria. Integrating climate and social factors into disease control strategies represents a high priority for optimizing the public health response and anticipating the geographic evolution of the African meningitis belt.
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Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview.
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Autor/in / Beteiligte Person: | Agier, Lydiane ; Martiny, Nadège ; Thiongane, Oumy ; Mueller, Judith E ; Paireau, Juliette ; Watkins, Eleanor R ; Irving, Tom J ; Koutangni, Thibaut ; Broutin, Hélène ; University, Lancaster ; Centre de Recherches de Climatologie UMR Biogéosciences (CRC) ; Biogéosciences UMR 6282 (BGS) ; Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS) ; Institut de recherche pour le développement (IRD Burkina Faso ) ; Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology ; Pasteur-Cnam Risques infectieux et émergents (PACRI) ; Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM) ; École des Hautes Études en Santé Publique EHESP (EHESP) ; Département Méthodes quantitatives en santé publique (METIS) ; University, Princeton ; University of Oxford ; University of Bristol Bristol ; Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) ; Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud ) ; Université Cheikh Anta Diop de Dakar Sénégal (UCAD) ; This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
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Zeitschrift: | ISSN: 1201-9712, 2016 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2016 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.ijid.2016.10.032 |
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