β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1
In: Viruses, 2023
academicJournal
Zugriff:
Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by Candida albicans and β-glucan in antiviral innate immunity. It showed that C. albicans and β-glucan promoted the expression of interferon-β (IFN-β) and interleukin-6 (IL-6) in mouse macrophages triggered by viral infection. In addition, β-glucan pretreatment attenuated the pathological damage induced by the virus in mouse lungs and promoted the expression of IFN-β. Mechanistically, β-glucan could promote the phosphorylation and ubiquitination of TANK Binding Kinase 1 (TBK1), a key protein of the innate immune pathway. These results suggest that β-glucan can promote innate antiviral immunity, and this bioactive material may be a potential therapeutic target for antiviral treatment.
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β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1
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Autor/in / Beteiligte Person: | Wang, Guolei ; Li, Zhiqiang ; Tian, Mingfu ; Cui, Xianghua ; Ma, Jun’e ; Liu, Siyu ; Ye, Chenglin ; Yuan, Li ; Qudus, Muhammad Suhaib ; Afaq, Uzair ; Wu, Kailang ; Liu, Xinghui ; Zhu, Chengliang |
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Zeitschrift: | Viruses, 2023 |
Veröffentlichung: | MDPI, 2023 |
Medientyp: | academicJournal |
DOI: | 10.3390/v15051204 |
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