Association between birth weight, preterm birth, and nonalcoholic fatty liver disease in a community‐based cohort
In: ISSN: 0270-9139, 2022
Online
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Zugriff:
International audience ; Background and AimsThe association between birth weight (BW) and metabolic outcomes has been described since the 1980s but NAFLD has been rarely studied. This study aimed to investigate the association between BW and NAFLD occurrence in adult subjects.Approach and ResultsThe study population consisted of participants from the French nationwide Constances cohort from 2012 to 2019. Participants with a history of chronic viral hepatitis or excessive alcohol consumption were excluded. Noninvasive diagnosis of NAFLD and fibrosis was performed using a combination of the Fatty Liver Index (FLI) and the Forns Index. The relationship between BW and NAFLD was analyzed with a sex-stratified logistic regression model adjusted for sociodemographic parameters, lifestyle, and birth term, whereas liver fibrosis was analyzed with a sex-stratified linear regression model. In total, 55,034 individuals with reliable BW were included (43% men, mean age: 38 years). NAFLD (FLI ≥ 60) was present in 5530 individuals (10%). Multivariate logistic regression showed a significant U-shaped relationship between BW and NAFLD, with no significant interaction with sex. A significant and slightly decreasing association was found between BW and Forns Index (β = −0.05; p = 0.04). Premature birth (OR, 1.23; 95% CI, 1.03–1.48 for birth between 33 and 37 weeks versus ≥ 37 weeks) was associated with NAFLD, with a significant direct effect of premature birth, and without an indirect effect of low BW in mediation analysis. Forns Index was not significantly higher in participants with preterm birth compared to full-term birth.ConclusionsThis large prospective adult-based cohort confirms the relationship between BW and NAFLD occurrence.
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Association between birth weight, preterm birth, and nonalcoholic fatty liver disease in a community‐based cohort
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| Autor/in / Beteiligte Person: | Amadou, Coralie ; Nabi, Oumarou ; Serfaty, Lawrence ; Lacombe, Karine ; Boursier, Jérôme ; Mathurin, Philippe ; Ribet, Céline ; de Ledinghen, Victor ; Zins, Marie ; Charles, Marie‐aline ; UFR Médecine Santé - Université Paris Cité (UFR Médecine UPCité) ; Université Paris Cité (UPCité) ; Centre Hospitalier Sud Francilien ; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) ; Hôpital de Hautepierre Strasbourg ; Centre de Recherche Saint-Antoine (CRSA) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) ; Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH) ; Université d'Angers (UA) ; Service d'Hépato-gastroentérologie CHU Lille ; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) ; Cohortes épidémiologiques en population (CONSTANCES) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité) ; Hôpital Haut-Lévêque CHU Bordeaux ; Bordeaux, CHU ; Bordeaux Research In Translational Oncology Bordeaux (BaRITOn) ; Université de Bordeaux (UB)-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Centre for Research in Epidemiology and Statistics ; Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; The Constances Cohort Study is supported and funded by the Caisse nationale d’assurance maladie. The Constances Cohort Study is an “Infrastructure nationale en Biologie et Santé” and received a grant from the National Research Agency, ANR (ANR-11-INBS-0002), and from the French Ministry of Research. Constances is also partly funded by Merck Sharp and Dohme, AstraZeneca, and Lundbeck. The findings and conclusions in this study are those of the authors and do not necessarily represent the views of the sponsors. ; ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011) |
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| Zeitschrift: | ISSN: 0270-9139, 2022 |
| Veröffentlichung: | HAL CCSD ; Wiley-Blackwell, 2022 |
| Medientyp: | academicJournal |
| DOI: | 10.1002/hep.32540 |
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