Rezistentiškų formų piktybinių navikų chemoterapijos potencijavimas hematoporfirino dariniams ; The potentiation of chemotherapy with porphyrins as a method of treatment for malignant tumors resistant to chemotherapy

Since 1990 the total of 20 patients with advanced malignant lesions have got sensitised tumors treatment in VUOI. All these patients underwent chemotherapy before the sensitised tumors treatment was provided for them. In all the cases chemotherapy was ineffective. The sensitizer delivered to malignant tissue was activated by red light which caused death of malignant tissues. Providing this treatment the derivative of hematoporphyrin was injected i/v for patients and 24, 48 and 72 h after the injection tumours were irradiated with a red light from the laser. As the malignant lesions were wide spread the radical sensitised tumors treatment was impossible. So such treatment was provided only for one small metastatical or primary tumor’s lesion. The usual chemotherapy was used 3-30 days after sensitised tumors treatment. As the result of such treatment the remission of the disease was established in 15 patients. The tumor’s regression was noticed in 11 patients.