Human MuStem cells, a promising therapeutic candidate for muscular dystrophies with immunomodulatory properties
In: Nantes Actualités Transplantation ; https://hal.science/hal-01595625 ; Nantes Actualités Transplantation, Jun 2016, 2016
Konferenz
Zugriff:
Nowadays, allogeneic cell-based therapeutic approaches for regenerative medecine are limited by graft rejection. To counteract this major deleterious effect, immunosuppressive regimens are developed and given to patients, improving their lifespan but causing in return severe adverse effects. Over the last years, a number of adult stem cell populations including mesenchymal stem cells (MSC) and vessel-associated stem cells were described for the treatment of genetic muscle diseases. Those cells were shown to display immunomodulatory properties by acting, directly or through the secretion of soluble factors, on a large number of immune cell partners (Cossu et al., 2012; English et al., 2013). Duchenne Muscular Dystrophy (DMD) is a degenerative muscle disease characterized notably by an inflammatory component that negatively impacts on muscle regeneration activity. In this context, these original immune features attributed to stem cells could be a great advantage to improve cell engraftment and efficiency. In the laboratory, we have isolated a population of muscle-derived stem cells from healthy dog muscle tissue, called cMuStem cells, and made the proof of concept of their systemic delivery efficiency in the preclinical GRMD canine model of DMD (Rouger et al, 2011; Robriquet et al, 2015). Recently, we managed to isolate the same population from Paravertebralis muscle of 9 to 15-years old patients free of known muscle disease (hMuStem cells). It was defined as a mixed population composed of both myogenic progenitors and mesenchymal perivascular cells, and characterized by a large proliferation rate, an oligopotency as well as an in vivo myogenic regenerative potential. The aim of the study was to determine whether hMuStem cells also exhibit immunomodulatory properties. Interestingly, our preliminary data show the ability of hMuStem cells from different donors to modulate allogeneic T cell proliferation and to secrete various immunomodulatory molecules (prostaglandin-E2, indoleamin-2,3-deoxygenase-1, heme ...
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Human MuStem cells, a promising therapeutic candidate for muscular dystrophies with immunomodulatory properties
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Autor/in / Beteiligte Person: | Lorant, Judith ; Jaulin, Nicolas ; Charrier, Marine ; Lieubeau-Teillet, Blandine ; Leroux, Isabelle ; Schleder, Cindy ; Magot, Armelle ; Hamel, Antoine ; Pereon, Yann ; Adjali, Oumeya ; Rouger, Karl ; Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher) ; École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE) ; Université de Nantes (UN)-Université de Nantes (UN) ; Institut National de la Recherche Agronomique (INRA) ; Immuno-Endocrinologie Cellulaire et Moléculaire (IECM) ; Centre de Référence des maladies neuromusculaires rares Nantes-Angers, Service des Explorations Fonctionnelles ; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) ; Service de Chirurgie Infantile |
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Zeitschrift: | Nantes Actualités Transplantation ; https://hal.science/hal-01595625 ; Nantes Actualités Transplantation, Jun 2016, 2016 |
Veröffentlichung: | HAL CCSD, 2016 |
Medientyp: | Konferenz |
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