Incidence of and Risk Factors for Venous Thromboembolism Among Hospitalized Patients with Cancer and COVID-19: Report from the COVID-19 and Cancer Consortium (CCC19) Registry
In: Blood, 2020
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Zugriff:
Introduction: Hospitalized patients with COVID-19 may have increased risk of venous thromboembolism (VTE) and pulmonary embolism (PE). Cancer and anti-cancer therapies are well-known additional risk factors for VTE. Nonetheless, the VTE risk in patients with both cancer and COVID-19 infection remains unknown as recent studies have not found an association due to sample size limitations. We report the incidence of and risk factors for VTE and PE among hospitalized patients with cancer and COVID-19. Methods: The COVID-19 and Cancer Consortium (CCC19) developed an international retrospective cohort study (NCT04354701) to investigate the clinical course and complications of COVID-19 among adult patients with an active or previous history of cancer. For the current study, cumulative incidences of clinically detected VTE and PE were analyzed among hospitalized patients with laboratory confirmed SARS-CoV-2. Pre-specified subgroup analysis was performed to examine the interaction between intensive care unit (ICU) admission and recent anti-cancer therapy on VTE outcomes. Bivariable logistic regression analyses were conducted to assess the association between baseline variables and VTE; unadjusted odds ratios (OR) and 95% confidence interval (CI) were reported. These variables included age, sex, obesity (BMI>30), race/ethnicity, performance status, comorbidities, blood type, history of VTE, recent surgery, recent anti-cancer therapy, cancer subtype VTE risk grouping (adapted from Khorana Score), pre-admission anticoagulant or antiplatelet use, and ICU admission status. Results: From March 17, 2020 to July 31, 2020, 3914 patients were enrolled in the CCC19 registry. For the present analysis, patients were excluded if they had inadequate follow-up <4 weeks (n=950), were not admitted to the hospital (n=1008), or had unknown VTE outcomes (n=327). Among the 1629 hospitalized patients, the median follow-up was 35 days. Patients were comprised from 3 countries (92% US, 6% Canada, 2% Spain), with a median age of 70, 45% ...
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Incidence of and Risk Factors for Venous Thromboembolism Among Hospitalized Patients with Cancer and COVID-19: Report from the COVID-19 and Cancer Consortium (CCC19) Registry
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Autor/in / Beteiligte Person: | Li, Ang ; Kuderer, Nicole M. ; Warner, Jeremy L. ; Desai, Aakash ; Shah, Dimpy P. ; Fu, Julie ; Li, Monica ; Zon, Rebecca ; Shah, Surbhi ; Gulati, Shuchi ; Khaki, Ali Raza ; Kulkarni, Amit ; Elshoury, Amro ; Thompson, Michael A. ; Grivas, Petros ; de Lima Lopes, Gilberto ; Shyr, Yu ; Pennell, Nathan A ; Schmidt, Andrew ; Friese, Christopher R ; Stover, Daniel ; Patel, Jaymin ; Halmos, Balazs ; Choueiri, Toni K. ; Peters, Solange ; Rivera, Donna R. ; Painter, Corrie ; Rini, Brian ; Lyman, Gary H. ; Connors, Jean M. ; Rosovsky, Rachel P. |
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Zeitschrift: | Blood, 2020 |
Veröffentlichung: | American Society of Hematology. Published by Elsevier Inc., 2020 |
Medientyp: | academicJournal |
DOI: | 10.1182/blood-2020-138834 |
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