In vivo pharmacokinetics and histology of STP0404 treated subjects.

A. SD rats were administrated with STP0404 by IV (1 and 5 mg/kg) and PO (2 and 10 mg/kg). B. Beagle dogs were administrated IV and PO (2 mg/kg). Plasma concentrations were determined by LC-MS for 24 h post administration (see Methods ). For A and B , data are presented as means of three independent experiments and error bars indicate the standard deviations from the means. C. Half-lives (T 1/2 ), area under the curve (AUC), maximum concentration (C max ), and bioavailability (F t ) from the administrated animals ( A and B ) were calculated. D. Histology of beagle dogs orally administrated with STP0404 (90 mg/kg) or vehicle for bladder, ureter, and kidney in 4-week GLP toxicology study. The entire GLP toxicology study’s results were summarized in S3 Table .