Risk factors for acquisition of meningococcal carriage in the African meningitis belt
In: Tropical Medicine & International Health ; https://hal-amu.archives-ouvertes.fr/hal-02263733 ; Tropical Medicine & International Health, John Wiley & Sons Ltd, 2019, 24 (4), pp.392-400. ⟨10.1111/tmi.13203⟩ ; ftccsdartic, 2019
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Zugriff:
International audience ; ObjectiveTo investigate potential risk factors for acquisition in seven countries of the meningitis belt.MethodsHouseholds were followed up every 2 weeks for 2 months, then monthly for a further 4 months. Pharyngeal swabs were collected from all available household members at each visit and questionnaires completed. Risks of acquisition over the whole study period and for each visit were analysed by a series of logistic regressions.ResultsOver the course of the study, acquisition was higher in: (i) 5-to 14-year olds, as compared with those 30 years or older (OR 3.6, 95% CI 1.4–9.9); (ii) smokers (OR 3.6, 95% CI 0.98–13); and (iii) those exposed to wood smoke at home (OR 2.6 95% CI 1.3–5.6). The risk of acquisition from one visit to the next was higher in those reporting a sore throat during the dry season (OR 3.7, 95% CI 2.0–6.7) and lower in those reporting antibiotic use (OR 0.17, 95% CI 0.03–0.56).ConclusionsAcquisition of meningococcal carriage peaked in school age children. Recent symptoms of sore throat during the dry season, but not during the rainy season, were associated with a higher risk of acquisition. Upper respiratory tract infections may be an important driver of epidemics in the meningitis belt.
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Risk factors for acquisition of meningococcal carriage in the African meningitis belt
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| Autor/in / Beteiligte Person: | Cooper, Laura ; Robson, Anna ; Trotter, Caroline ; Aseffa, Abraham ; Collard, Jean-Marc ; Daugla, Doumagoum Moto ; Diallo, Aldiouma ; Hodgson, Abraham ; Jusot, Jean‐François ; Omotara, Babatunji ; Hassan‐King, Musa ; Manigart, Olivier ; Nascimento, Maria ; Woukeu, Arouna ; Chandramohan, Daniel ; Borrow, Ray ; Maiden, Martin ; Greenwood, Brian ; Stuart, James ; University of Cambridge UK (CAM) ; Armauer Hansen Research Institute (AHRI) ; Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES) ; Réseau International des Instituts Pasteur (RIIP) ; Unité de Bactériologie Expérimentale Antananarivo, Madagascar (IPM) ; Institut Pasteur de Madagascar ; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) ; Centre de Support en Santé Internationale N'Djamena, Tchad (CSSI) ; Institut de recherche pour le développement Dakar, Sénégal (IRD Hann Maristes) ; Navrongo Health Research Centre Navrongo, Ghana (NHRC) ; University of Maiduguri ; London School of Hygiene and Tropical Medicine (LSHTM) ; Vaccine Evaluation Unit Manchester ; Manchester Medical Microbiology Partnership United Kingdom (MMMP)-Public Health England London ; University of Oxford Oxford ; The work of the MenAfriCar Consortium was supported by grants from the Bill & Melinda Gates Foundation and from the Wellcome Trust. ; Institutions and individual members of the MenAfriCar consortium who contributed to this study. Armauer Hansen Research Institute, Addis Ababa, Ethiopia: Oumer Ali, Abraham Aseffa (PI), Ahmed Bedru, Tsehaynesh Lema, Tesfaye Moti, Yenenesh Tekletsion, Alemayehu Worku, Haimanot Guebre Xabher (deceased), Lawrence Yamuah. Centre de Recherche Médicale et Sanitaire (CERMES), Niamey, Niger (Member of the International Network of Pasteur Institutes): Rahamatou Moustapha Boukary, Jean-Marc Collard (PI), Ibrahim Dan Dano, Ibrahim Habiboulaye, Bassira Issaka, Jean-François Jusot, Sani Ousmane, Issoufa Rabe. Centre de Support en Santé International (CSSI), N'Djamena, Chad: Doumagoum Moto Daugla (PI), Jean Pierre Gami, Kadidja Gamougam, Lodoum Mbainadji, Nathan Naibei, Maxime Narbé, Jacques Toralta. Centre pour les Vaccins en Développement, Bamako, Mali: Abdoulaye Berthe, Kanny Diallo, Mahamadou Keita, Uma Onwuchekwa, Samba O. Sow (PI), Boubou Tamboura, Awa Traore, Alou Toure. Centers for Disease Control, Atlanta, USA: Tom Clark, Leonard Mayer. Department of Community Medicine, University of Maiduguri, Maiduguri, Nigeria: Mary Amodu, Omeiza Beida, Galadima Gadzama, Babatunji Omotara (PI), Zailani Sambo, Shuaibu Yahya. Faculty of Infectious Disease, London School of Hygiene & Tropical Medicine, London, UK: Daniel Chandramohan, Brian M. Greenwood (PI), Musa Hassan-King, Olivier Manigart, Maria Nascimento, James M. Stuart, Arouna Woukeu. Princeton University, USA: Nicole E. Basta. Public Health England Vaccine Evaluation Unit, Manchester, UK: Xilian Bai, Ray Borrow, Helen Findlow. Institut de Recherche pour le Développement, Dakar, Senegal: Serge Alavo, Hubert Bassene, Aldiouma Diallo (PI), Marietou Dieng, Souleymane Doucouré, Jules François Gomis, Assane Ndiaye, Cheikh Sokhna, Jean François Trape. Navrongo Health Research Centre, Navrongo, Ghana: Bugri Akalifa (deceased), Abudulai Forgor (deceased), Abraham Hodgson (PI), Isaac Osei, Stephen L. Quaye, John Williams, Peter Wontuo. University of Bristol, UK: Thomas Irving. University of Cambridge, UK ; Caroline L. Trotter. University of Oxford, UK: Julia Bennett, Dorothea Hill, Odile Harrison, Martin C.J. Maiden, Lisa Rebbetts, Eleanor Watkins. |
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| Zeitschrift: | Tropical Medicine & International Health ; https://hal-amu.archives-ouvertes.fr/hal-02263733 ; Tropical Medicine & International Health, John Wiley & Sons Ltd, 2019, 24 (4), pp.392-400. ⟨10.1111/tmi.13203⟩ ; ftccsdartic, 2019 |
| Veröffentlichung: | HAL CCSD ; John Wiley & Sons Ltd, 2019 |
| Medientyp: | academicJournal |
| DOI: | 10.1111/tmi.13203 |
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