Comparison of Two Zinc Hydride Precatalysts for Selective Dehydrogenative Borylation of Terminal Alkynes: A Detailed Mechanistic Study
2023
Zeitungsartikel
Zugriff:
The conjugated bis-guanidinate-stabilized zinc hydride complex ( I )-precatalyzed chemoselective dehydroborylation of a wide array of terminal alkynes with excellent yields is reported. Further, precatalyst I is compared with a newly synthesized Diethyl NacNac zinc hydride precatalyst ( III ) for selective dehydroborylation of terminal alkynes, and it is discovered that precatalyst I is more active than III . We have studied intra- and intermolecular chemoselective dehydroborylation of terminal alkynes over other reducible functionalities such as alkene, ester, isocyanide, nitro, and heterocycles. The highly efficient precatalyst I shows a turnover number of 48.5 and turnover frequency of up to 60.5 h –1 in the dehydroborylation of 1-ethynyl-4-fluorobenzene ( 1i ). A plausible mechanism for selective dehydrogenative borylation of alkynes has been proposed based on active catalyst isolation and a series of stoichiometric reactions.
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Comparison of Two Zinc Hydride Precatalysts for Selective Dehydrogenative Borylation of Terminal Alkynes: A Detailed Mechanistic Study
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Autor/in / Beteiligte Person: | Rajata Kumar Sahoo (9291745) ; Arukela Ganesh Patro (14372437) ; Nabin Sarkar (6180491) ; Sharanappa Nembenna (2389492) |
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Veröffentlichung: | 2023 |
Medientyp: | Zeitungsartikel |
DOI: | 10.1021/acsomega.2c07381.s001 |
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