Comparison of the efficiency of chopped and non-rectangular electrical stimulus waveforms in activating small vagus nerve fibers
In: ISSN: 0165-0270 ; Journal of Neuroscience Methods ; https://hal-lirmm.ccsd.cnrs.fr/lirmm-02072446 ; Journal of Neuroscience Methods, 2019, 320, pp.1-8. ⟨10.1016/j.jneumeth.2019.02.017⟩, 2019
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International audience ; Background : In the context of morbid obesity, vagus nerve stimulation could be used to control gastric function targeting the small afferent B-fibers and C-fibers. Compared to large A-fibers, activation thresholds of these small efferent fibers are 10 to 100 times greater, inducing technical constraints and possible nerve damages. Although rectangular waveform is commonly used in nerve stimulation, recent modeling and experimental studies suggest that non-rectangular waveforms could reduced the charge injected by the stimulator.New method : The objective of the present study is to evaluate the charge injection of complex waveforms such as the ramp, quarter sine and chopped pulses in the context of vagus nerve stimulation. We performed in-vivo study on the porcine abdominal vagus nerves and evaluated charge injection at activation thresholds. A modeling study was performed to further extent the results obtained in-vivo.Comparison with existing method : Compared to the rectangular pulse, the ramp and quarter sine waveforms activated gastric fibers with the lowest charge injection: −23.2% and −30.1% respectively. The efficacy of chopped pulses is questioned through the consideration of the strength-duration curve.Conclusion : Continuous ramp and quarter sine waveforms effectively activate small diameter fibers. These pulse shapes may be considered for long-term vagus nerve stimulation. The results predicted by computational models were qualitatively consistent with experiments. This suggested the relevance of using modeling in the context of complex waveforms prior to future in-vivo tests.
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Comparison of the efficiency of chopped and non-rectangular electrical stimulus waveforms in activating small vagus nerve fibers
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Autor/in / Beteiligte Person: | Dali, Mélissa ; Picq, Chloé ; Rossel, Olivier ; Maciejasz, Pawel ; Malbert, Charles-Henri ; Guiraud, David ; Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN) ; Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM) ; Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria) ; AXONIC - OBELIA dept ; MXM-Laboratoires de Techologies Médicales ; University Hospital of Montpellier ; Otto Bock Healthcare GmbH ; US 1395 ANI-SCAN, INRA ; Institut National de la Recherche Agronomique (INRA) ; MD, PM, CP, and DG drafted the manuscript and all co-authors re-vised the manuscript. CHM, PM, OR and DG designed the stimulationprotocols. CHM designed and performed the surgical approach onporcine subjects. PM and CP acquired and pre-processed experimentaldata. CP, PM and MD performed statistical analyses. MD and DG de-fined the numerical implementation of models and algorithms andprocessed the simulated data. This work was supported by the INTENSEproject with a grant from BPI France within the Investments for theFuture program in France. |
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Zeitschrift: | ISSN: 0165-0270 ; Journal of Neuroscience Methods ; https://hal-lirmm.ccsd.cnrs.fr/lirmm-02072446 ; Journal of Neuroscience Methods, 2019, 320, pp.1-8. ⟨10.1016/j.jneumeth.2019.02.017⟩, 2019 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2019 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.jneumeth.2019.02.017 |
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