The PQS signalling pathway in P . aeruginosa .
2021
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Zugriff:
The PqsABCDE proteins synthesize HHQ, which is converted to PQS by PqsH and also HQNO in conjunction with PqsL. Both HHQ and PQS are released by the cells into the extracellular environment and are taken back up by neighboring cells. Autoinduction occurs when either HHQ or PQS binds to PqsR and amplifies expression of the pqsABCDE operon. The pqsE gene product has dual functions contributing to AQ biosynthesis as a thioesterase and also via an AQ-independent, thioesterase-independent mechanism for e.g. pyocyanin, rhamnolipid and lectin production as well as biofilm maturation. The conversion of HHQ to PQS confers additional functionalities since PQS unlike HHQ induces microvesicle formation and is a potent iron chelator.
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The PQS signalling pathway in P . aeruginosa .
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Autor/in / Beteiligte Person: | Eliza Ye-Chen Soh (11356153) ; Frances Smith (11356156) ; Maxime Rémi Gimenez (11356159) ; Liang Yang (15035) ; Rebecca Munk Vejborg (11356162) ; Matthew Fletcher (437507) ; Nigel Halliday (797002) ; Sophie Bleves (474775) ; Stephan Heeb (91858) ; Miguel Cámara (141074) ; Michael Givskov (235463) ; Kim R. Hardie (8493378) ; Tim Tolker-Nielsen (243072) ; Bérengère Ize (848548) ; Paul Williams (191800) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.ppat.1009425.g001 |
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