Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
In: Sliz , E , Tyrmi , J S , Rahmioglu , N , Zondervan , K T , Becker , C M , Uimari , O , Kettunen , J , Palotie , A , Daly , M , Riley-Gills , B , Jacob , H , Paul , D , Matakidou , A , Platt , A , Runz , H , John , S , Okafo , G , Lawless , N , Salminen-Mankonen , H , Plenge , R , Maranville , J , McCarthy , M , Ehm , M G , Auro , K , Longerich , S , Fox , C , Malarstig , A , Klinger , K , Chatelain , C , Gossel , M , Estrada , K , Graham , R , Yang , R , O'Donnell , C , Mäkelä , T P , Kaprio , J , Virolainen , P , Hakanen , A , Kilpi , T , Perola , M , Partanen , J , Pitkäranta , A , Raivio , T , Serpi , R , Laitinen , T , Kosma , V-M , Laukkanen , J , Hautalahti , M , Tuovila , O , Pakkanen , R , Waring , J , Riley-Gillis , B , Rahimov , F , Tachmazidou , I , Chen , C-Y , Ding , Z , Jung , M , Biswas , S , Pendergrass , R , Pulford , D , Raghavan , N , Huertas-Vazquez , A , Sul , J-H , Hu , X , Hedman , A , Rivas , M , Waterworth , D , Renaud , N , Obeidat , M , Ripatti , S , Schleutker , J , Arvas , M , Carpen , O , Hinttala , R , Mannermaa , A , Aalto-Setala , K , Kahonen , M , Mäkelä , J , Kalviainen , R , Julkunen , V , Soininen , H , Remes , A , Hiltunen , M , Peltola , J , Raivio , M , Tienari , P , Rinne , J , Kallionpaa , R , Partanen , J , Abbasi , A , Ziemann , A , Smaoui , N , Lehtonen , A , Eaton , S , Lahdenpera , S , Bowers , N , Teng , E , Xu , F , Addis , L , Eicher , J , Li , Q S , He , K , Khramtsova , E , Färkkilä , M , Koskela , J , Pikkarainen , S , Jussila , A , Kaukinen , K , Blomster , T , Kiviniemi , M , Voutilainen , M , Lu , T , McCarthy , L , Hart , A , Guan , M , Miller , J , Kalpala , K , Miller , M , Eklund , K , Palomaki , A , Isomaki , P , Pirila , L , Kaipiainen-Seppanen , O , Huhtakangas , J , Mars , N , Lertratanakul , A , Hochfeld , M , Gordillo , J E , Farias , F , Bing , N , Pelkonen , M , Kauppi , P , Kankaanranta , H , Harju , T , Lahesmaa , R , Lassi , G , Chen , H , Betts , J , Mishra , R , Mouded , M , Ngo , D , Niiranen , T , Vaura , F , Salomaa , V , Metsarinne , K , Aittokallio , J , Hernesniemi , J , Gordin , D , Sinisalo , J , Taskinen , M-R , Tuomi , T , Elliott , A , Reeve , M P , Ruotsalainen , S , Challis , B , Chu , A , Reilly , D , Mendelson , M , Parkkinen , J , Meretoja , T , Joensuu , H , Mattson , J , Salminen , E , Auranen , A , Karihtala , P , Auvinen , P , Elenius , K , Pitkänen , E , Popovic , R , Schutzman , J , Kulkarni , D , Porello , A , Loboda , A , Lehtonen , H , McDonough , S , Vuoti , S , Kaarniranta , K , Turunen , J A , Ollila , T , Uusitalo , H , Karjalainen , J , Liu , M , Loomis , S , Strauss , E , Chen , H , Tasanen , K , Huilaja , L , Hannula-Jouppi , K , Salmi , T , Peltonen , S , Koulu , L , Choy , D , Wu , Y , Pussinen , P , Salminen , A , Salo , T , Rice , D , Nieminen , P , Palotie , U , Siponen , M , Suominen , L , Mäntylä , P , Gursoy , U , Anttonen , V , Sipila , K , Laivuori , H , Kurra , V , Kotaniemi-Talonen , L , Heikinheimo , O , Kalliala , I , Aaltonen , L , Jokimaa , V , Vaarasmaki , M , Morin-Papunen , L , Niinimaki , M , Piltonen , T , Kivinen , K , Widen , E , Tukiainen , T , Välimäki , N , Laakkonen , E , Silven , H , Arffman , R , Savukoski , S , Laisk , T , Pujol , N , Kumar , J , Hovatta , I , Isometsä , E , Ollila , H , Suvisaari , J , Als , T D , Mäkitie , A , Bizaki-Vallaskangas , A , Toppila-Salmi , S , Willberg , T , Saarentaus , E , Aarnisalo , A , Rahikkala , E , Aittomaki , K , Åberg , F , Kurki , M , Havulinna , A , Mehtonen , J , Palta , P , Hassan , S , Parolo , P D B , Zhou , W , Maasha , M , Lemmela , S , Liu , A , Lehisto , A , Ganna , A , Llorens , V , Heyne , H , Rämö , J , Rodosthenous , R , Strausz , S , Palotie , T , Palin , K , Garcia-Tabuenca , J , Siirtola , H , Kiiskinen , T , Lee , J , Tsuo , K , Kristiansson , K , Hyvarinen , K , Ritari , J , Pylkas , K , Karjalainen , M , Mantere , T , Kangasniemi , E , Heikkinen , S , Pitkanen , N , Lessard , S , Chatelain , C , Terho , P , Wahlfors , T , Punkka , E , Siltanen , S , Kuopio , T , Jalanko , A , Shen , H-Y , Kajanne , R , Aavikko , M , Palin , H , Linna , M-M , Kanai , M , Zheng , Z , Lahtela , L E , Kaunisto , M , Kilpeläinen , E , Sipila , T P , Dada , O A , Ghazal , A , Kytölä , A , Weldatsadik , R , Donner , K , Loukola , A , Laiho , P , Sistonen , T , Kaiharju , E , Laukkanen , M , Jarvensivu , E , Lahteenmaki , S , Mannikko , L , Wong , R , Toivola , A , Brunfeldt , M , Mattsson , H , Koskelainen , S , Hiekkalinna , T , Paajanen , T , Pärn , K , Kals , M , Luo , S , Padmanabhuni , S S , Niemi , M , Gracia-Tabuenca , J , Helminen , M , Luukkaala , T , Vahatalo , I , Tammerluoto , J , Smith , S , Southerington , T & Lehto , P 2023 , ' Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata ' , Nature Communications , vol. 14 , no. 542 ORCID: /0000-0001-9301-3078/work/147910540; ORCID: /0000-0002-5990-7892/work/147911378; ORCID: /0000-0003-0281-2507/work/147911446; ORCID: /0000-0002-2527-5874/work/147911498; ORCID: /0000-0001-5956-2399/work/147912416; ORCID: /0000-0001-6839-4286/work/147912480; ORCID: /0000-0001-7011-0422/work/147912747; ORCID: /0000-0001-6739-1606/work/147912751; ORCID: /0000-0003-3563-1876/work/147912903; ORCID: /0000-0002-9569-9146/work/147913361; ORCID: /0000-0001-6039-0088/work/147913399; ORCID: /0000-0002-0250-8559/work/147914018; ORCID: /0000-0002-6229-3588/work/147914096; ORCID: /0000-0003-0542-5967/work/147915519; ORCID: /0000-0002-8306-6202/work/147915771; ORCID: /0000-0001-7576-090X/work/147917090; ORCID: /0000-0003-1494-8292/work/147917115; ORCID: /0000-0003-0890-6686/work/147917191; ORCID: /0000-0002-0154-7222/work/147917208; ORCID: /0000-0001-9320-7008/work/147917248; ORCID: /0000-0002-8475-7187/work/147917260; ORCID: /0000-0002-2691-0710/work/147917638; ORCID: /0000-0002-5302-6429/work/147917648; ORCID: /0000-0002-6429-5149/work/147917905; ORCID: /0000-0002-8147-240X/work/147918309; ORCID: /0000-0003-2972-470X/work/147918314; ORCID: /0000-0002-7259-5993/work/147918378; ORCID: /0000-0002-0169-5137/work/147918409; ORCID: /0000-0002-6946-9195/work/147918440; ORCID: /0000-0002-4869-8044/work/147918663; ORCID: /0000-0003-3490-3702/work/147918703; ORCID: /0000-0002-1135-7625/work/147918874; ORCID: /0000-0002-7664-0587/work/155091554; ORCID: /0000-0001-9190-4336/work/155648780; 0b7d5d22-2a84-41b1-a009-55881c872724; 001034930800003
Online
academicJournal
Zugriff:
Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics. ; Peer reviewed
Titel: |
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
|
---|---|
Autor/in / Beteiligte Person: | Sliz, Eeva ; Tyrmi, Jaakko S. ; Rahmioglu, Nilufer ; Zondervan, Krina T. ; Becker, Christian M. ; Uimari, Outi ; Kettunen, Johannes ; Palotie, Aarno ; Daly, Mark ; Riley-Gills, Bridget ; Jacob, Howard ; Paul, Dirk ; Matakidou, Athena ; Platt, Adam ; Runz, Heiko ; John, Sally ; Okafo, George ; Lawless, Nathan ; Salminen-Mankonen, Heli ; Plenge, Robert ; Maranville, Joseph ; McCarthy, Mark ; Ehm, Margaret G. ; Auro, Kirsi ; Longerich, Simonne ; Fox, Caroline ; Malarstig, Anders ; Klinger, Katherine ; Chatelain, Clement ; Gossel, Matthias ; Estrada, Karol ; Graham, Robert ; Yang, Robert ; O'Donnell, Chris ; Mäkelä, Tomi P. ; Kaprio, Jaakko ; Virolainen, Petri ; Hakanen, Antti ; Kilpi, Terhi ; Perola, Markus ; Partanen, Jukka ; Pitkäranta, Anne ; Raivio, Taneli ; Serpi, Raisa ; Laitinen, Tarja ; Kosma, Veli-Matti ; Laukkanen, Jari ; Hautalahti, Marco ; Tuovila, Outi ; Pakkanen, Raimo ; Waring, Jeffrey ; Riley-Gillis, Bridget ; Rahimov, Fedik ; Tachmazidou, Ioanna ; Chen, Chia-Yen ; Ding, Zhihao ; Jung, Marc ; Biswas, Shameek ; Pendergrass, Rion ; Pulford, David ; Raghavan, Neha ; Huertas-Vazquez, Adriana ; Sul, Jae-Hoon ; Hu, Xinli ; Hedman, Asa ; Rivas, Manuel ; Waterworth, Dawn ; Renaud, Nicole ; Obeidat, Ma'en ; Ripatti, Samuli ; Schleutker, Johanna ; Arvas, Mikko ; Carpen, Olli ; Hinttala, Reetta ; Mannermaa, Arto ; Aalto-Setala, Katriina ; Kahonen, Mika ; Mäkelä, Johanna ; Kalviainen, Reetta ; Julkunen, Valtteri ; Soininen, Hilkka ; Remes, Anne ; Hiltunen, Mikko ; Peltola, Jukka ; Raivio, Minna ; Tienari, Pentti ; Rinne, Juha ; Kallionpaa, Roosa ; Partanen, Juulia ; Abbasi, Ali ; Ziemann, Adam ; Smaoui, Nizar ; Lehtonen, Anne ; Eaton, Susan ; Lahdenpera, Sanni ; Bowers, Natalie ; Teng, Edmond ; Xu, Fanli ; Addis, Laura ; Eicher, John ; Li, Qingqin S. ; He, Karen ; Khramtsova, Ekaterina ; Färkkilä, Martti ; Koskela, Jukka ; Pikkarainen, Sampsa ; Jussila, Airi ; Kaukinen, Katri ; Blomster, Timo ; Kiviniemi, Mikko ; Voutilainen, Markku ; Lu, Tim ; McCarthy, Linda ; Hart, Amy ; Guan, Meijian ; Miller, Jason ; Kalpala, Kirsi ; Miller, Melissa ; Eklund, Kari ; Palomaki, Antti ; Isomaki, Pia ; Pirila, Laura ; Kaipiainen-Seppanen, Oili ; Huhtakangas, Johanna ; Mars, Nina ; Lertratanakul, Apinya ; Hochfeld, Marla ; Gordillo, Jorge Esparza ; Farias, Fabiana ; Bing, Nan ; Pelkonen, Margit ; Kauppi, Paula ; Kankaanranta, Hannu ; Harju, Terttu ; Lahesmaa, Riitta ; Lassi, Glenda ; Chen, Hubert ; Betts, Joanna ; Mishra, Rajashree ; Mouded, Majd ; Ngo, Debby ; Niiranen, Teemu ; Vaura, Felix ; Salomaa, Veikko ; Metsarinne, Kaj ; Aittokallio, Jenni ; Hernesniemi, Jussi ; Gordin, Daniel ; Sinisalo, Juha ; Taskinen, Marja-Riitta ; Tuomi, Tiinamaija ; Elliott, Amanda ; Reeve, Mary Pat ; Ruotsalainen, Sanni ; Challis, Benjamin ; Chu, Audrey ; Reilly, Dermot ; Mendelson, Mike ; Parkkinen, Jaakko ; Meretoja, Tuomo ; Joensuu, Heikki ; Mattson, Johanna ; Salminen, Eveliina ; Auranen, Annika ; Karihtala, Peeter ; Auvinen, Paivi ; Elenius, Klaus ; Pitkänen, Esa ; Popovic, Relja ; Schutzman, Jennifer ; Kulkarni, Diptee ; Porello, Alessandro ; Loboda, Andrey ; Lehtonen, Heli ; McDonough, Stefan ; Vuoti, Sauli ; Kaarniranta, Kai ; Turunen, Joni A. ; Ollila, Terhi ; Uusitalo, Hannu ; Karjalainen, Juha ; Liu, Mengzhen ; Loomis, Stephanie ; Strauss, Erich ; Chen, Hao ; Tasanen, Kaisa ; Huilaja, Laura ; Hannula-Jouppi, Katariina ; Salmi, Teea ; Peltonen, Sirkku ; Koulu, Leena ; Choy, David ; Wu, Ying ; Pussinen, Pirkko ; Salminen, Aino ; Salo, Tuula ; Rice, David ; Nieminen, Pekka ; Palotie, Ulla ; Siponen, Maria ; Suominen, Liisa ; Mäntylä, Päivi ; Gursoy, Ulvi ; Anttonen, Vuokko ; Sipila, Kirsi ; Laivuori, Hannele ; Kurra, Venla ; Kotaniemi-Talonen, Laura ; Heikinheimo, Oskari ; Kalliala, Ilkka ; Aaltonen, Lauri ; Jokimaa, Varpu ; Vaarasmaki, Marja ; Morin-Papunen, Laure ; Niinimaki, Maarit ; Piltonen, Terhi ; Kivinen, Katja ; Widen, Elisabeth ; Tukiainen, Taru ; Välimäki, Niko ; Laakkonen, Eija ; Silven, Heidi ; Arffman, Riikka ; Savukoski, Susanna ; Laisk, Triin ; Pujol, Natalia ; Kumar, Janet ; Hovatta, Iiris ; Isometsä, Erkki ; Ollila, Hanna ; Suvisaari, Jaana ; Als, Thomas Damm ; Mäkitie, Antti ; Bizaki-Vallaskangas, Argyro ; Toppila-Salmi, Sanna ; Willberg, Tytti ; Saarentaus, Elmo ; Aarnisalo, Antti ; Rahikkala, Elisa ; Aittomaki, Kristiina ; Åberg, Fredrik ; Kurki, Mitja ; Havulinna, Aki ; Mehtonen, Juha ; Palta, Priit ; Hassan, Shabbeer ; Parolo, Pietro Della Briotta ; Zhou, Wei ; Maasha, Mutaamba ; Lemmela, Susanna ; Liu, Aoxing ; Lehisto, Arto ; Ganna, Andrea ; Llorens, Vincent ; Heyne, Henrike ; Rämö, Joel ; Rodosthenous, Rodos ; Strausz, Satu ; Palotie, Tuula ; Palin, Kimmo ; Garcia-Tabuenca, Javier ; Siirtola, Harri ; Kiiskinen, Tuomo ; Lee, Jiwoo ; Tsuo, Kristin ; Kristiansson, Kati ; Hyvarinen, Kati ; Ritari, Jarmo ; Pylkas, Katri ; Karjalainen, Minna ; Mantere, Tuomo ; Kangasniemi, Eeva ; Heikkinen, Sami ; Pitkanen, Nina ; Lessard, Samuel ; Terho, Perttu ; Wahlfors, Tiina ; Punkka, Eero ; Siltanen, Sanna ; Kuopio, Teijo ; Jalanko, Anu ; Shen, Huei-Yi ; Kajanne, Risto ; Aavikko, Mervi ; Palin, Henna ; Linna, Malla-Maria ; Kanai, Masahiro ; Zheng, Zhili ; Lahtela, L. Elisa ; Kaunisto, Mari ; Kilpeläinen, Elina ; Sipila, Timo P. ; Dada, Oluwaseun Alexander ; Ghazal, Awaisa ; Kytölä, Anastasia ; Weldatsadik, Rigbe ; Donner, Kati ; Loukola, Anu ; Laiho, Päivi ; Sistonen, Tuuli ; Kaiharju, Essi ; Laukkanen, Markku ; Jarvensivu, Elina ; Lahteenmaki, Sini ; Mannikko, Lotta ; Wong, Regis ; Toivola, Auli ; Brunfeldt, Minna ; Mattsson, Hannele ; Koskelainen, Sami ; Hiekkalinna, Tero ; Paajanen, Teemu ; Pärn, Kalle ; Kals, Mart ; Luo, Shuang ; Padmanabhuni, Shanmukha Sampath ; Niemi, Marianna ; Gracia-Tabuenca, Javier ; Helminen, Mika ; Luukkaala, Tiina ; Vahatalo, Iida ; Tammerluoto, Jyrki ; Smith, Sarah ; Southerington, Tom ; Lehto, Petri ; Centre of Excellence in Complex Disease Genetics ; Research Programs Unit ; Aarno Palotie / Principal Investigator ; Institute for Molecular Medicine Finland ; Genomics of Neurological and Neuropsychiatric Disorders ; Communications and Community Relations ; Helsinki Institute of Life Science HiLIFE ; Department of Biochemistry and Developmental Biology ; Lab, Mäkelä ; Molecular and Integrative Biosciences Research Programme ; HUS Head and Neck Center ; Clinicum ; Department of Physiology ; Doctoral Programme in Social Sciences ; Department of Public Health ; Samuli Olli Ripatti / Principal Investigator ; Complex Disease Genetics ; Faculty Common Matters (Faculty of Social Sciences) ; HUSLAB ; Precision Cancer Pathology ; Department of Pathology ; Olli Mikael Carpen / Principal Investigator ; Faculty Common Matters (Faculty of Medicine) ; HUS Helsinki and Uusimaa Hospital District ; Neurocenter, HUS ; Department of Neurosciences ; University of Helsinki ; HUS Abdominal Center ; Department of Medicine ; HUS Inflammation Center ; Department of Dermatology, Allergology and Venereology ; HUS Heart and Lung Center ; Marja-Riitta Taskinen Research Group ; Tiinamaija Tuomi Research Group ; HUS Comprehensive Cancer Center ; Department of Oncology ; Heikki Joensuu / Principal Investigator ; Machine learning in biomedicine ; Medicum ; Department of Oral and Maxillofacial Diseases ; David Paul Cracroft Rice / Principal Investigator ; HUS Gynecology and Obstetrics ; Department of Obstetrics and Gynecology ; Department of Medical and Clinical Genetics ; ATG - Applied Tumor Genomics ; Lauri Antti Aaltonen / Principal Investigator ; Elisabeth Ingrid Maria Widen / Principal Investigator ; Genomic Discoveries and Clinical Translation ; Genomics of Sex Differences ; Department of Computer Science ; Department of Psychology and Logopedics ; Genetics ; Mind and Matter ; Iiris Hovatta / Principal Investigator ; Department of Psychiatry ; Psychiatry, HUS ; Korva-, nenä- ja kurkkutautien klinikka ; Kristiina Aittomäki / Principal Investigator ; IV kirurgian klinikka ; Data Science Genetic Epidemiology Lab ; Bank, Bio ; Molecular Systems Biology |
Link: | |
Quelle: | Sliz , E , Tyrmi , J S , Rahmioglu , N , Zondervan , K T , Becker , C M , Uimari , O , Kettunen , J , Palotie , A , Daly , M , Riley-Gills , B , Jacob , H , Paul , D , Matakidou , A , Platt , A , Runz , H , John , S , Okafo , G , Lawless , N , Salminen-Mankonen , H , Plenge , R , Maranville , J , McCarthy , M , Ehm , M G , Auro , K , Longerich , S , Fox , C , Malarstig , A , Klinger , K , Chatelain , C , Gossel , M , Estrada , K , Graham , R , Yang , R , O'Donnell , C , Mäkelä , T P , Kaprio , J , Virolainen , P , Hakanen , A , Kilpi , T , Perola , M , Partanen , J , Pitkäranta , A , Raivio , T , Serpi , R , Laitinen , T , Kosma , V-M , Laukkanen , J , Hautalahti , M , Tuovila , O , Pakkanen , R , Waring , J , Riley-Gillis , B , Rahimov , F , Tachmazidou , I , Chen , C-Y , Ding , Z , Jung , M , Biswas , S , Pendergrass , R , Pulford , D , Raghavan , N , Huertas-Vazquez , A , Sul , J-H , Hu , X , Hedman , A , Rivas , M , Waterworth , D , Renaud , N , Obeidat , M , Ripatti , S , Schleutker , J , Arvas , M , Carpen , O , Hinttala , R , Mannermaa , A , Aalto-Setala , K , Kahonen , M , Mäkelä , J , Kalviainen , R , Julkunen , V , Soininen , H , Remes , A , Hiltunen , M , Peltola , J , Raivio , M , Tienari , P , Rinne , J , Kallionpaa , R , Partanen , J , Abbasi , A , Ziemann , A , Smaoui , N , Lehtonen , A , Eaton , S , Lahdenpera , S , Bowers , N , Teng , E , Xu , F , Addis , L , Eicher , J , Li , Q S , He , K , Khramtsova , E , Färkkilä , M , Koskela , J , Pikkarainen , S , Jussila , A , Kaukinen , K , Blomster , T , Kiviniemi , M , Voutilainen , M , Lu , T , McCarthy , L , Hart , A , Guan , M , Miller , J , Kalpala , K , Miller , M , Eklund , K , Palomaki , A , Isomaki , P , Pirila , L , Kaipiainen-Seppanen , O , Huhtakangas , J , Mars , N , Lertratanakul , A , Hochfeld , M , Gordillo , J E , Farias , F , Bing , N , Pelkonen , M , Kauppi , P , Kankaanranta , H , Harju , T , Lahesmaa , R , Lassi , G , Chen , H , Betts , J , Mishra , R , Mouded , M , Ngo , D , Niiranen , T , Vaura , F , Salomaa , V , Metsarinne , K , Aittokallio , J , Hernesniemi , J , Gordin , D , Sinisalo , J , Taskinen , M-R , Tuomi , T , Elliott , A , Reeve , M P , Ruotsalainen , S , Challis , B , Chu , A , Reilly , D , Mendelson , M , Parkkinen , J , Meretoja , T , Joensuu , H , Mattson , J , Salminen , E , Auranen , A , Karihtala , P , Auvinen , P , Elenius , K , Pitkänen , E , Popovic , R , Schutzman , J , Kulkarni , D , Porello , A , Loboda , A , Lehtonen , H , McDonough , S , Vuoti , S , Kaarniranta , K , Turunen , J A , Ollila , T , Uusitalo , H , Karjalainen , J , Liu , M , Loomis , S , Strauss , E , Chen , H , Tasanen , K , Huilaja , L , Hannula-Jouppi , K , Salmi , T , Peltonen , S , Koulu , L , Choy , D , Wu , Y , Pussinen , P , Salminen , A , Salo , T , Rice , D , Nieminen , P , Palotie , U , Siponen , M , Suominen , L , Mäntylä , P , Gursoy , U , Anttonen , V , Sipila , K , Laivuori , H , Kurra , V , Kotaniemi-Talonen , L , Heikinheimo , O , Kalliala , I , Aaltonen , L , Jokimaa , V , Vaarasmaki , M , Morin-Papunen , L , Niinimaki , M , Piltonen , T , Kivinen , K , Widen , E , Tukiainen , T , Välimäki , N , Laakkonen , E , Silven , H , Arffman , R , Savukoski , S , Laisk , T , Pujol , N , Kumar , J , Hovatta , I , Isometsä , E , Ollila , H , Suvisaari , J , Als , T D , Mäkitie , A , Bizaki-Vallaskangas , A , Toppila-Salmi , S , Willberg , T , Saarentaus , E , Aarnisalo , A , Rahikkala , E , Aittomaki , K , Åberg , F , Kurki , M , Havulinna , A , Mehtonen , J , Palta , P , Hassan , S , Parolo , P D B , Zhou , W , Maasha , M , Lemmela , S , Liu , A , Lehisto , A , Ganna , A , Llorens , V , Heyne , H , Rämö , J , Rodosthenous , R , Strausz , S , Palotie , T , Palin , K , Garcia-Tabuenca , J , Siirtola , H , Kiiskinen , T , Lee , J , Tsuo , K , Kristiansson , K , Hyvarinen , K , Ritari , J , Pylkas , K , Karjalainen , M , Mantere , T , Kangasniemi , E , Heikkinen , S , Pitkanen , N , Lessard , S , Chatelain , C , Terho , P , Wahlfors , T , Punkka , E , Siltanen , S , Kuopio , T , Jalanko , A , Shen , H-Y , Kajanne , R , Aavikko , M , Palin , H , Linna , M-M , Kanai , M , Zheng , Z , Lahtela , L E , Kaunisto , M , Kilpeläinen , E , Sipila , T P , Dada , O A , Ghazal , A , Kytölä , A , Weldatsadik , R , Donner , K , Loukola , A , Laiho , P , Sistonen , T , Kaiharju , E , Laukkanen , M , Jarvensivu , E , Lahteenmaki , S , Mannikko , L , Wong , R , Toivola , A , Brunfeldt , M , Mattsson , H , Koskelainen , S , Hiekkalinna , T , Paajanen , T , Pärn , K , Kals , M , Luo , S , Padmanabhuni , S S , Niemi , M , Gracia-Tabuenca , J , Helminen , M , Luukkaala , T , Vahatalo , I , Tammerluoto , J , Smith , S , Southerington , T & Lehto , P 2023 , ' Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata ' , Nature Communications , vol. 14 , no. 542 ORCID: /0000-0001-9301-3078/work/147910540; ORCID: /0000-0002-5990-7892/work/147911378; ORCID: /0000-0003-0281-2507/work/147911446; ORCID: /0000-0002-2527-5874/work/147911498; ORCID: /0000-0001-5956-2399/work/147912416; ORCID: /0000-0001-6839-4286/work/147912480; ORCID: /0000-0001-7011-0422/work/147912747; ORCID: /0000-0001-6739-1606/work/147912751; ORCID: /0000-0003-3563-1876/work/147912903; ORCID: /0000-0002-9569-9146/work/147913361; ORCID: /0000-0001-6039-0088/work/147913399; ORCID: /0000-0002-0250-8559/work/147914018; ORCID: /0000-0002-6229-3588/work/147914096; ORCID: /0000-0003-0542-5967/work/147915519; ORCID: /0000-0002-8306-6202/work/147915771; ORCID: /0000-0001-7576-090X/work/147917090; ORCID: /0000-0003-1494-8292/work/147917115; ORCID: /0000-0003-0890-6686/work/147917191; ORCID: /0000-0002-0154-7222/work/147917208; ORCID: /0000-0001-9320-7008/work/147917248; ORCID: /0000-0002-8475-7187/work/147917260; ORCID: /0000-0002-2691-0710/work/147917638; ORCID: /0000-0002-5302-6429/work/147917648; ORCID: /0000-0002-6429-5149/work/147917905; ORCID: /0000-0002-8147-240X/work/147918309; ORCID: /0000-0003-2972-470X/work/147918314; ORCID: /0000-0002-7259-5993/work/147918378; ORCID: /0000-0002-0169-5137/work/147918409; ORCID: /0000-0002-6946-9195/work/147918440; ORCID: /0000-0002-4869-8044/work/147918663; ORCID: /0000-0003-3490-3702/work/147918703; ORCID: /0000-0002-1135-7625/work/147918874; ORCID: /0000-0002-7664-0587/work/155091554; ORCID: /0000-0001-9190-4336/work/155648780; 0b7d5d22-2a84-41b1-a009-55881c872724; 001034930800003 |
Veröffentlichung: | Nature Publishing Group, 2023 |
Medientyp: | academicJournal |
ISBN: | 978-0-01-034930-6 (print) ; 0-01-034930-8 (print) |
DOI: | 10.1038/s41467-023-35974-7 , https://doi.org/10.1038/s41467-023-35974-7 |
Schlagwort: |
|
Sonstiges: |
|