Estrogen receptor {alpha}-351 XbaIG and -397 PvuIIC-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma
Oxford University Press, 2007
academicJournal
Zugriff:
Endometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor α (ERα)-351 A>G ( Xba I) and -397 T>C ( Pvu II) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis ( n = 112), (ii) leiomyoma ( n = 106) and (iii) normal controls ( n = 110). Genomic DNA was obtained from peripheral leukocytes. ERα-351 A/G Xba I and -397 T/C Pvu II polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ERα-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ERα mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ERα-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ERα-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ERα-351 Xba I*G- and -397 Pvu II*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses.
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Estrogen receptor {alpha}-351 XbaIG and -397 PvuIIC-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma
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Autor/in / Beteiligte Person: | Hsieh, Y. Y. ; Wang, Y. K. ; Chang, C. C. ; Lin, C. S. |
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Veröffentlichung: | Oxford University Press, 2007 |
Medientyp: | academicJournal |
DOI: | 10.1093/molehr/gal099 |
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