Reliability of parylene-based multi-electrode arrays chronically implanted on adult rat brains, and evidence of electrical stimulation on contact impedance
In: ISSN: 1741-2560, 2019
Online
academicJournal
Zugriff:
International audience ; OBJECTIVE: The goal of this study was to evaluate the long-term behavior of the surface electrode through electrochemical characterization and follow up of implanted parylene/platinum microelectrodes.APPROACH: To this aim, we designed and manufactured specific planar electrodes for cortical implantation for a rat model. This work was included in the INTENSE® project, one of the goals of which was to prove the feasibility of selective neural recording or stimulation with cuff electrodes around the vagus nerve.MAIN RESULTS: After a 12-week implantation on a rat model, we can report that these microelectrodes have withstood in-vivo use. Regarding the biocompatibility of the electrodes (materials and manufacturing process), no adverse effect was reported. Indeed, after the three months implantation, we characterized limited tissue reaction beneath the electrodes and showed an increase and a stabilization of their impedance. Interestingly, the follow up of the electrochemical impedance combined with electrical stimulation highlighted a drop of the impedance up to 60% @1kHz after ten minutes of electrical stimulation at 110Hz.
| Titel: |
Reliability of parylene-based multi-electrode arrays chronically implanted on adult rat brains, and evidence of electrical stimulation on contact impedance
|
|---|---|
| Autor/in / Beteiligte Person: | Torres, Napoleon ; Ratel, David ; Cretallaz, Céline ; Gaude, Christophe ; Maubert, Sandrine ; Divoux, Jean-Louis ; Henry, Christine ; Guiraud, David ; Sauter-Starace, Fabien ; Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI) ; Direction de Recherche Technologique (CEA) (DRT (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Clinatec - Centre de recherche biomédicale Edmond J.Safra (SCLIN) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ) ; Centre de Recherches du Service de Santé des Armées (CRSSA) ; Service de Santé des Armées ; AXONIC - OBELIA dept ; MXM-Laboratoires de Techologies Médicales ; Sorin Group Clamart ; Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN) ; Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM) ; Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria) |
| Link: | |
| Zeitschrift: | ISSN: 1741-2560, 2019 |
| Veröffentlichung: | HAL CCSD ; IOP Publishing, 2019 |
| Medientyp: | academicJournal |
| DOI: | 10.1088/1741-2552/ab3836 |
| Schlagwort: |
|
| Sonstiges: |
|