Effect of Intravenously Administered Lipoxygenase Metabolites on Rat Tracheal Mucous Gel Layer Thickness
In: International Archives of Allergy and Immunology, Jg. 90 (1989), Heft 3, S. 307-309
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Zugriff:
The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D 4 and E 4 (LTD 4 , LTE 4 ) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE > 12-HETE ≥ 5-HETE > LTD 4 ≥ LTE 4 . Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.
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Effect of Intravenously Administered Lipoxygenase Metabolites on Rat Tracheal Mucous Gel Layer Thickness
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Autor/in / Beteiligte Person: | Yanni, John M. ; Foxwell, Marianne H. ; Whitman, Laura L. ; Smith, William L. ; Nolan, Joseph C. |
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Zeitschrift: | International Archives of Allergy and Immunology, Jg. 90 (1989), Heft 3, S. 307-309 |
Veröffentlichung: | S. Karger AG, 1989 |
Medientyp: | academicJournal |
ISSN: | 1018-2438 |
DOI: | 10.1159/000235043 |
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