Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa
In: Front Immunol, 2022
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Zugriff:
Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. To evaluate the effect of recent malaria on COVID-19 we assessed a subgroup of individuals participating in a longitudinal cohort COVID-19 serosurvey that were also undergoing intensive malaria monitoring as part of antimalarial vaccine trials during the 2020 transmission season in Mali. These communities experienced a high incidence of primarily asymptomatic or mild COVID-19 during 2020 and 2021. In 1314 individuals, 711 were parasitemic during the 2020 malaria transmission season; 442 were symptomatic with clinical malaria and 269 had asymptomatic infection. Presence of parasitemia was not associated with new COVID-19 seroconversion (29.7% (211/711) vs. 30.0% (181/603), p=0.9038) or with rates of reported symptomatic seroconversion during the malaria transmission season. In the subsequent dry season, prior parasitemia was not associated with new COVID-19 seroconversion (30.2% (133/441) vs. 31.2% (108/346), p=0.7499), with symptomatic seroconversion, or with reversion from seropositive to seronegative (prior parasitemia: 36.2% (64/177) vs. no parasitemia: 30.1% (37/119), p=0.3842). After excluding participants with asymptomatic infection, clinical malaria was also not associated with COVID-19 serostatus or symptomatic seroconversion when compared to participants with no parasitemia during the monitoring period. In communities with intense seasonal malaria and a high incidence of asymptomatic or mild COVID-19, we did not demonstrate a relationship between recent malaria and subsequent response to COVID-19. Lifetime exposure, rather than recent infection, may be responsible for any effect of malaria on COVID-19 severity.
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Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa
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Autor/in / Beteiligte Person: | Woodford, John ; Sagara, Issaka ; Diawara, Halimatou ; Assadou, Mahamadoun Hamady ; Katile, Abdoulaye ; Attaher, Oumar ; Issiaka, Djibrilla ; Santara, Gaoussou ; Soumbounou, Ibrahim H. ; Traore, Seydou ; Traore, Moussa ; Dicko, Oumar M. ; Niambele, Sidi Mohamed ; Mahamar, Almahamoudou ; Kamate, Bourama ; Haidara, Bayaya ; Sissoko, Kourane ; Sankare, Seydou ; Diarra, Sadio dite Koni ; Zeguime, Amatigue ; Doritchamou, Justin Y. A. ; Zaidi, Irfan ; Dicko, Alassane ; Duffy, Patrick E. |
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Zeitschrift: | Front Immunol, 2022 |
Veröffentlichung: | Frontiers Media S.A., 2022 |
Medientyp: | academicJournal |
DOI: | 10.3389/fimmu.2022.959697 |
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