Increased Ratio of Tumor Necrosis Factor-{alpha} to Interleukin-10 Production Is Associated with Schistosoma haematobium-Induced Urinary-Tract Morbidity
Oxford University Press, 2004
academicJournal
Zugriff:
Bladder and kidney disease, which affect ∼25%–C30% of subjects infected with Schistosoma haematobium , are mediated by T cell-dependent granulomatous responses to schistosome eggs. To determine why only some infected subjects develop disease, we examined the hypothesis that infected Kenyan subjects with ultrasounddetected urinary-tract morbidity ( n = 49) had dysregulated cytokine production leading to enhanced granulomatous responses, compared with subjects of similar age and intensity of infection without morbidity ( n = 100). Peripheral blood mononuclear cells from subjects with morbidity produced 8-fold greater levels of egg antigen-driven tumor necrosis factor (TNF)-α and had a 99-fold greater mean TNF-α:interleukin (IL)- 10 ratio, compared with subjects without disease. No differences in cytokine response to non-Cegg-derived schistosome antigens were observed between groups. Subjects with morbidity had increased TNF-α production in response to endotoxin, suggesting an innate hyperresponsiveness. These results indicate that increased TNF-α production, relative to that of IL-10, is associated with developing bladder-wall morbidity with S. haematobium infection.
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Increased Ratio of Tumor Necrosis Factor-{alpha} to Interleukin-10 Production Is Associated with Schistosoma haematobium-Induced Urinary-Tract Morbidity
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Autor/in / Beteiligte Person: | Wamachi, Alex N. ; Mayadev, Jyoti S. ; Mungai, Peter L. ; Magak, Phillip L. ; Ouma, John H. ; Magambo, Japhet K. ; Muchiri, Eric M. ; Koech, Davy K. ; King, Charles H. ; King, Chistopher |
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Veröffentlichung: | Oxford University Press, 2004 |
Medientyp: | academicJournal |
DOI: | 10.1086/425579 |
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