Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia ...
figshare, 2023
academicJournal
Zugriff:
Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical manifestation of severe malaria in such regions. Although innate immune response genes are known to influence the development of SMA, the role of natural killer (NK) cells in malaria pathogenesis remains largely undefined. As such, we examined the impact of genetic variation in the gene encoding a primary NK cell receptor, natural cytotoxicity-triggering receptor 3 (NCR3), on the occurrence of malaria and SMA episodes over time. Methods Susceptibility to malaria, SMA, and all-cause mortality was determined in carriers of NCR3 genetic variants (i.e., rs2736191:C > G and rs11575837:C > T) and their haplotypes. The prospective observational study was conducted over a 36 mos. follow-up period in a cohort of children (n = 1,515, aged 1.9–40 mos.) residing in a ...
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Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia ...
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Autor/in / Beteiligte Person: | Onyango, Clinton O. ; Cheng, Qiuying ; Munde, Elly O. ; Raballah, Evans ; Anyona, Samuel B. ; McMahon, Benjamin H. ; Lambert, Christophe G. ; Onyango, Patrick O. ; Schneider, Kristan A. ; Perkins, Douglas J. ; Ouma, Collins |
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Veröffentlichung: | figshare, 2023 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.c.6834077 |
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