Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages
In: EISSN: 2057-1577 ; Virus Evolution ; https://hal.inrae.fr/hal-04548415 ; Virus Evolution, 2024, 10 (1), pp.veae012. ⟨10.1093/ve/veae012⟩, 2024
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International audience ; Peste des petits ruminants virus (PPRV) causes a highly infectious disease affecting mainly goats and sheep in large parts of Africa, Asia, and the Middle East and has an important impact on the global economy and food security. Full genome sequencing of PPRV strains has proved to be critical to increasing our understanding of PPR epidemiology and to inform the ongoing global efforts for its eradication. However, the number of full PPRV genomes published is still limited and with a heavy bias towards recent samples and genetic Lineage IV (LIV), which is only one of the four existing PPRV lineages. Here, we generated genome sequences for twenty-five recent (2010–6) and seven historical (1972–99) PPRV samples, focusing mainly on Lineage II (LII) in West Africa. This provided the first opportunity to compare the evolutionary pressures and history between the globally dominant PPRV genetic LIV and LII, which is endemic in West Africa. Phylogenomic analysis showed that the relationship between PPRV LII strains was complex and supported the extensive transboundary circulation of the virus within West Africa. In contrast, LIV sequences were clearly separated per region, with strains from West and Central Africa branched as a sister clade to all other LIV sequences, suggesting that this lineage also has an African origin. Estimates of the time to the most recent common ancestor place the divergence of modern LII and LIV strains in the 1960s–80s, suggesting that this period was particularly important for the diversification and spread of PPRV globally. Phylogenetic relationships among historical samples from LI, LII, and LIII and with more recent samples point towards a high genetic diversity for all these lineages in Africa until the 1970s–80s and possible bottleneck events shaping PPRV’s evolution during this period. Molecular evolution analyses show that strains belonging to LII and LIV have evolved under different selection pressures. Differences in codon usage and adaptative selection ...
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Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages
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Autor/in / Beteiligte Person: | Courcelle, Maxime ; Salami, Habib ; Tounkara, Kadidia ; Lo, Modou Moustapha ; Ba, Aminata ; Diop, Mariame ; Niang, Mamadou ; Sidibe, Cheick Abou Kounta ; Sery, Amadou ; Dakouo, Marthin ; Kaba, Lanceï ; Sidime, Youssouf ; Keyra, Mohamed ; Diallo, Alpha Oumar Sily ; El Mamy, Ahmed Bezeid ; El Arbi, Ahmed Salem ; Barry, Yahya ; Isselmou, Ekaterina ; Habiboullah, Habiboullah ; Doumbia, Baba ; Gueya, Mohamed Baba ; Awuni, Joseph ; Odoom, Theophilus ; Ababio, Patrick Tetteh ; Tawiahyingar, Daniel Nana Yaw ; Coste, Caroline ; Guendouz, Samia ; Kwiatek, Olivier ; Libeau, Geneviève ; Bataille, Arnaud ; Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) ; Laboratoire National d'Elevage et de Recherches Vétérinaires Dakar (LNERV) ; Institut Sénégalais de Recherches Agricoles Dakar (ISRA) ; Laboratoire Central Vétérinaire Bamako, Mali ; Food and Agriculture Organization of the United Nations, Global Emergency Centre for Transboundary Animal Diseases (ECTAD) ; Food and Agriculture Organization of the United Nations (FAO) ; FAO Regional Office for Africa Accra (FAO) ; Food and Agriculture Organization of the United Nations Rome, Italie (FAO) ; Vecteurs - Infections tropicales et méditerranéennes (VITROME) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA) ; Institut Supérieur des Sciences et de Médecine Vétérinaire de Dalaba (ISSMV/D) ; Office National de Recherche et de Développement de l’Elevage (ONARDEL) ; A.B. is supported by a grant from the European Commission Animal Health and Welfare European Research Area Network (ANIHWA) for the Project 'Improved Understanding of Epidemiology of PPR' (IUEPPR), and by a grant (SI2.756606) from the European Commission Directorate General for Health and Food Safety awarded to the European Union Reference Laboratory for peste des petits ruminants. |
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Zeitschrift: | EISSN: 2057-1577 ; Virus Evolution ; https://hal.inrae.fr/hal-04548415 ; Virus Evolution, 2024, 10 (1), pp.veae012. ⟨10.1093/ve/veae012⟩, 2024 |
Veröffentlichung: | HAL CCSD ; Oxford University Press, 2024 |
Medientyp: | academicJournal |
DOI: | 10.1093/ve/veae012 |
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