Comparative analysis of the macroscale structural connectivity in the macaque and human brain
Public Library of Science, 2014
Online
academicJournal
Zugriff:
The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
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Comparative analysis of the macroscale structural connectivity in the macaque and human brain
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Autor/in / Beteiligte Person: | Goulas, Alexandros ; Bastiani, Matteo ; Bezgin, Gleb ; Uylings, Harry B.M. ; Roebroeck, Alard ; Stiers, Peter ; Hilgetag, Claus C. |
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Veröffentlichung: | Public Library of Science, 2014 |
Medientyp: | academicJournal |
ISSN: | 1553-734X (print) |
DOI: | 10.1371/journal.pcbi.1003529 |
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