Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the Global Pediatric Diarrhea Surveillance network
In: BMJ Glob Health, 2022
academicJournal
Zugriff:
INTRODUCTION: Diarrhoea remains a leading cause of child morbidity and mortality. Systematically collected and analysed data on the aetiology of hospitalised diarrhoea in low-income and middle-income countries are needed to prioritise interventions. METHODS: We established the Global Pediatric Diarrhea Surveillance network, in which children under 5 years hospitalised with diarrhoea were enrolled at 33 sentinel surveillance hospitals in 28 low-income and middle-income countries. Randomly selected stool specimens were tested by quantitative PCR for 16 causes of diarrhoea. We estimated pathogen-specific attributable burdens of diarrhoeal hospitalisations and deaths. We incorporated country-level incidence to estimate the number of pathogen-specific deaths on a global scale. RESULTS: During 2017–2018, 29 502 diarrhoea hospitalisations were enrolled, of which 5465 were randomly selected and tested. Rotavirus was the leading cause of diarrhoea requiring hospitalisation (attributable fraction (AF) 33.3%; 95% CI 27.7 to 40.3), followed by Shigella (9.7%; 95% CI 7.7 to 11.6), norovirus (6.5%; 95% CI 5.4 to 7.6) and adenovirus 40/41 (5.5%; 95% CI 4.4 to 6.7). Rotavirus was the leading cause of hospitalised diarrhoea in all regions except the Americas, where the leading aetiologies were Shigella (19.2%; 95% CI 11.4 to 28.1) and norovirus (22.2%; 95% CI 17.5 to 27.9) in Central and South America, respectively. The proportion of hospitalisations attributable to rotavirus was approximately 50% lower in sites that had introduced rotavirus vaccine (AF 20.8%; 95% CI 18.0 to 24.1) compared with sites that had not (42.1%; 95% CI 33.2 to 53.4). Globally, we estimated 208 009 annual rotavirus-attributable deaths (95% CI 169 561 to 259 216), 62 853 Shigella-attributable deaths (95% CI 48 656 to 78 805), 36 922 adenovirus 40/41-attributable deaths (95% CI 28 469 to 46 672) and 35 914 norovirus-attributable deaths (95% CI 27 258 to 46 516). CONCLUSIONS: Despite the substantial impact of rotavirus vaccine introduction, rotavirus ...
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Aetiology and incidence of diarrhoea requiring hospitalisation in children under 5 years of age in 28 low-income and middle-income countries: findings from the Global Pediatric Diarrhea Surveillance network
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Autor/in / Beteiligte Person: | Cohen, Adam L ; Platts-Mills, James A ; Nakamura, Tomoka ; Operario, Darwin J ; Antoni, Sébastien ; Mwenda, Jason M ; Weldegebriel, Goitom ; Rey-Benito, Gloria ; de Oliveira, Lucia H ; Ortiz, Claudia ; Daniels, Danni S ; Videbaek, Dovile ; Singh, Simarjit ; Njambe, Emmanuel ; Sharifuzzaman, Mohamed ; Grabovac, Varja ; Nyambat, Batmunkh ; Logronio, Josephine ; Armah, George ; Dennis, Francis E ; Seheri, Mapaseka L ; Magagula, Nokululeko ; Mphahlele, Jeffrey ; Fumian, Tulio M ; Maciel, Irene T A ; Gagliardi Leite, Jose Paulo ; Esona, Matthew D ; Bowen, Michael D ; Samoilovich, Elena ; Semeiko, Galina ; Abraham, Dilip ; Giri, Sidhartha ; Praharaj, Ira ; Kang, Gagandeep ; Thomas, Sarah ; Bines, Julie ; Liu, Na ; Kyu, Hmwe H ; Doxey, Matthew ; Rogawski McQuade, Elizabeth T ; McMurry, Timothy L ; Liu, Jie ; Houpt, Eric R ; Tate, Jacqueline E ; Parashar, Umesh D ; Serhan, Fatima |
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Zeitschrift: | BMJ Glob Health, 2022 |
Veröffentlichung: | BMJ Publishing Group, 2022 |
Medientyp: | academicJournal |
DOI: | 10.1136/bmjgh-2022-009548 |
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