ALLINI structures and STP0404 activities.
2021
Bild
Zugriff:
A. Quinoline-based BI224436, B. Benzothiazole-based GS-9822, C. Pyridine-based KF116, D. Pyrrolopyridine-based STP0404. The conserved chemical moiety containing tert-butoxy and carboxylic acid groups are marked by “]”. E. In vitro anti-HIV-1 efficacy of STP0404 against HIV-1 NL4-3 and 89.6 strains in indicated cell lines. TI : Minimal therapeutic index values were calculated with 50% in vitro inhibitory concentration values (IC 50 ) and 10 μM where no sign of cytotoxicity was observed during tissue culture cytotoxicity measurements (TC 50 ) of all tested compounds in both MT4 and CEMx174 cell lines.
Titel: |
ALLINI structures and STP0404 activities.
|
---|---|
Autor/in / Beteiligte Person: | Tatsuya Maehigashi (1344159) ; Seohyun Ahn (11172117) ; Uk-Il Kim (11172120) ; Jared Lindenberger (11172123) ; Adrian Oo (11172126) ; Pratibha C. Koneru (6298775) ; Bijan Mahboubi (5853317) ; Alan N. Engelman (795355) ; Mamuka Kvaratskhelia (43017) ; Kyungjin Kim (140317) ; Baek Kim (66773) |
Link: | |
Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.ppat.1009671.g001 |
Schlagwort: |
|
Sonstiges: |
|