Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
In: Open Access funding provided by University of Helsinki including Helsinki University Central Hospital.; Lahti , J , Tuominen , S , Yang , Q , Pergola , G , Ahmad, 2023, S. 4419
Online
academicJournal
Zugriff:
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes. ; Peer reviewed
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Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
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| Autor/in / Beteiligte Person: | Lahti, Jari ; Tuominen, Samuli ; Yang, Qiong ; Pergola, Giulio ; Ahmad, Shahzad ; Amin, Najaf ; Armstrong, Nicola J. ; Beiser, Alexa ; Bey, Katharina ; Bis, Joshua C. ; Boerwinkle, Eric ; Bressler, Jan ; Campbell, Archie ; Campbell, Harry ; Chen, Qiang ; Corley, Janie ; Cox, Simon R. ; Davies, Gail ; De Jager, Philip L. ; Derks, Eske M. ; Faul, Jessica D. ; Fitzpatrick, Annette L. ; Fohner, Alison E. ; Ford, Ian ; Fornage, Myriam ; Gerring, Zachary ; Grabe, Hans J. ; Grodstein, Francine ; Gudnason, Vilmundur ; Simonsick, Eleanor ; Holliday, Elizabeth G. ; Joshi, Peter K. ; Kajantie, Eero ; Kaprio, Jaakko ; Karell, Pauliina ; Kleineidam, Luca ; Knol, Maria J. ; Kochan, Nicole A. ; Kwok, John B. ; Leber, Markus ; Lam, Max ; Lee, Teresa ; Li, Shuo ; Loukola, Anu ; Luck, Tobias ; Marioni, Riccardo E. ; Mather, Karen A. ; Medland, Sarah ; Mirza, Saira S. ; Nalls, Mike A. ; Nho, Kwangsik ; O'Donnell, Adrienne ; Oldmeadow, Christopher ; Painter, Jodie ; Pattie, Alison ; Reppermund, Simone ; Risacher, Shannon L. ; Rose, Richard J. ; Sadashivaiah, Vijay ; Scholz, Markus ; Satizabal, Claudia L. ; Schofield, Peter W. ; Schraut, Katharina E. ; Scott, Rodney J. ; Simino, Jeannette ; Smith, Albert V. ; Smith, Jennifer A. ; Stott, David J. ; Surakka, Ida ; Teumer, Alexander ; Thalamuthu, Anbupalam ; Trompet, Stella ; Turner, Stephen T. ; van der Lee, Sven J. ; Villringer, Arno ; Voelker, Uwe ; Wilson, Robert S. ; Wittfeld, Katharina ; Vuoksimaa, Eero ; Xia, Rui ; Yaffe, Kristine ; Yu, Lei ; Zare, Habil ; Zhao, Wei ; Ames, David ; Attia, John ; Bennett, David A. ; Brodaty, Henry ; Chasman, Daniel I. ; Goldman, Aaron L. ; Hayward, Caroline ; Ikram, M. Arfan ; Jukema, J. Wouter ; Kardia, Sharon L. R. ; Lencz, Todd ; Loeffler, Markus ; Mattay, Venkata S. ; Palotie, Aarno ; Psaty, Bruce M. ; Ramirez, Alfredo ; Ridker, Paul M. ; Riedel-Heller, Steffi G. ; Sachdev, Perminder S. ; Saykin, Andrew J. ; Scherer, Martin ; Schofield, Peter R. ; Sidney, Stephen ; Starr, John M. ; Trollor, Julian ; Ulrich, William ; Wagner, Michael ; Weir, David R. ; Wilson, James F. ; Wright, Margaret J. ; Weinberger, Daniel R. ; Debette, Stephanie ; Eriksson, Johan G. ; Mosley, Thomas H. ; Launer, Lenore J. ; van Duijn, Cornelia M. ; Deary, Ian J. ; Seshadri, Sudha ; Räikkönen, Katri ; Department of Psychology and Logopedics ; University of Helsinki ; HUS Children and Adolescents ; yksikkö, Lastentautien ; Hospital, Children's ; Clinicum ; Helsinki University Hospital Area ; Institute for Molecular Medicine Finland ; Department of Public Health ; HUSLAB ; HUS Helsinki and Uusimaa Hospital District ; Cognitive and Brain Aging ; Faculty Common Matters (Faculty of Medicine) ; Centre of Excellence in Complex Disease Genetics ; Research Programs Unit ; Aarno Palotie / Principal Investigator ; Genomics of Neurological and Neuropsychiatric Disorders ; Johan Eriksson / Principal Investigator ; Department of General Practice and Primary Health Care ; Medicum |
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| Zeitschrift: | Open Access funding provided by University of Helsinki including Helsinki University Central Hospital.; Lahti , J , Tuominen , S , Yang , Q , Pergola , G , Ahmad, 2023, S. 4419 |
| Veröffentlichung: | Nature Publishing Group, 2023 |
| Medientyp: | academicJournal |
| DOI: | 10.1038/s41380-022-01710-8 |
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