Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
In: ISSN: 2041-1723, 2019
Online
academicJournal
Zugriff:
International audience ; Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
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Autor/in / Beteiligte Person: | Czamara, Darina ; Eraslan, Gökçen ; Page, Christian, M ; Lahti, Jari ; Lahti-Pulkkinen, Marius ; Hämäläinen, Esa ; Kajantie, Eero ; Laivuori, Hannele ; Villa, Pia, M ; Reynolds, Rebecca, M ; Nystad, Wenche ; Håberg, Siri, E ; London, Stephanie, J ; O’donnell, Kieran, J ; Garg, Elika ; Meaney, Michael, J ; Entringer, Sonja ; Wadhwa, Pathik, D ; Buss, Claudia ; Jones, Meaghan, J ; Lin, David, T S ; Macisaac, Julie, L ; Kobor, Michael, S ; Koen, Nastassja ; Zar, Heather, J ; Koenen, Karestan, C ; Dalvie, Shareefa ; Stein, Dan, J ; Kondofersky, Ivan ; Müller, Nikola, S ; Theis, Fabian, J ; Wray, Naomi, R ; Ripke, Stephan ; Mattheisen, Manuel ; Trzaskowski, Maciej ; Byrne, Enda, M ; Abdellaoui, Abdel ; Adams, Mark, J ; Agerbo, Esben ; Air, Tracy, M ; Andlauer, Till, F M ; Bacanu, Silviu-Alin ; Bækvad-Hansen, Marie ; Beekman, Aartjan, T F ; Bigdeli, Tim, B ; Blackwood, Douglas, H R ; Bryois, Julien ; Buttenschøn, Henriette, N ; Bybjerg-Grauholm, Jonas ; Cai, Na ; Castelao, Enrique ; Christensen, Jane, Hvarregaard ; Clarke, Toni-Kim ; Coleman, Jonathan, R I ; Colodro-Conde, Lucía ; Couvy-Duchesne, Baptiste ; Craddock, Nick ; Crawford, Gregory, E ; Davies, Gail ; Deary, Ian, J ; Degenhardt, Franziska ; Derks, Eske, M ; Direk, Nese ; Dolan, Conor, V ; Dunn, Erin, C ; Eley, Thalia, C ; Escott-Price, Valentina ; Kiadeh, Farnush, Farhadi Hassan ; Finucane, Hilary, K ; Forstner, Andreas, J ; Frank, Josef ; Gaspar, Héléna, A ; Gill, Michael ; Goes, Fernando, S ; Gordon, Scott, D ; Grove, Jakob ; Hall, Lynsey, S ; Hansen, Christine, Søholm ; Hansen, Thomas, F ; Herms, Stefan ; Hickie, Ian, B ; Hoffmann, Per ; Homuth, Georg ; Horn, Carsten ; Hottenga, Jouke-Jan ; Hougaard, David, M ; Ising, Marcus ; Jansen, Rick ; Jorgenson, Eric ; Knowles, James, A ; Kohane, Isaac, S ; Kraft, Julia ; Kretzschmar, Warren, W ; Krogh, Jesper ; Kutalik, Zoltán ; Li, Yihan ; Lind, Penelope, A ; Macintyre, Donald, J ; Mackinnon, Dean, F ; Maier, Robert, M ; Maier, Wolfgang ; Marchini, Jonathan ; Mbarek, Hamdi ; Mcgrath, Patrick ; Mcguffin, Peter ; Medland, Sarah, E ; Mehta, Divya ; Middeldorp, Christel, M ; Mihailov, Evelin ; Milaneschi, Yuri ; Milani, Lili ; Mondimore, Francis, M ; Montgomery, Grant, W ; Mostafavi, Sara ; Mullins, Niamh ; Nauck, Matthias ; Ng, Bernard ; Nivard, Michel, G ; Nyholt, Dale, R ; O’reilly, Paul, F ; Oskarsson, Hogni ; Owen, Michael, J ; Painter, Jodie, N ; Pedersen, Carsten, Bøcker ; Pedersen, Marianne, Giørtz ; Peterson, Roseann, E ; Pettersson, Erik ; Peyrot, Wouter, J ; Pistis, Giorgio ; Posthuma, Danielle ; Quiroz, Jorge, A ; Qvist, Per ; Rice, John, P ; Riley, Brien, P ; Rivera, Margarita ; Mirza, Saira, Saeed ; Schoevers, Robert ; Schulte, Eva, C ; Shen, Ling ; Shi, Jianxin ; Shyn, Stanley, I ; Sigurdsson, Engilbert ; Sinnamon, Grant, C B ; Smit, Johannes, H ; Smith, Daniel, J ; Stefansson, Hreinn ; Steinberg, Stacy ; Streit, Fabian ; Strohmaier, Jana ; Tansey, Katherine, E ; Teismann, Henning ; Teumer, Alexander ; Thompson, Wesley ; Thomson, Pippa, A ; Thorgeirsson, Thorgeir, E ; Traylor, Matthew ; Treutlein, Jens ; Trubetskoy, Vassily ; Uitterlinden, André, G ; Umbricht, Daniel ; van der Auwera, Sandra ; van Hemert, Albert, M ; Viktorin, Alexander ; Visscher, Peter, M ; Wang, Yunpeng ; Webb, Bradley, T ; Weinsheimer, Shantel, Marie ; Wellmann, Jürgen ; Willemsen, Gonneke ; Witt, Stephanie, H ; Wu, Yang ; Xi, Hualin, S ; Yang, Jian ; Zhang, Futao ; Arolt, Volker ; Baune, Bernhard, T ; Berger, Klaus ; Boomsma, Dorret, I ; Cichon, Sven ; Dannlowski, Udo ; de Geus, E, J C ; Depaulo, J, Raymond ; Domenici, Enrico ; Domschke, Katharina ; Esko, Tõnu ; Grabe, Hans, J ; Hamilton, Steven, P ; Hayward, Caroline ; Heath, Andrew, C ; Kendler, Kenneth, S ; Kloiber, Stefan ; Lewis, Glyn ; Li, Qingqin, S ; Lucae, Susanne ; Madden, Pamela, a F ; Magnusson, Patrik, K ; Martin, Nicholas, G ; Mcintosh, Andrew, M ; Metspalu, Andres ; Mors, Ole ; Mortensen, Preben, Bo ; Müller-Myhsok, Bertram ; Nordentoft, Merete ; Nöthen, Markus, M ; O’donovan, Michael, C ; Paciga, Sara, A ; Pedersen, Nancy, L ; Penninx, Brenda, W J H ; Perlis, Roy, H ; Porteous, David, J ; Potash, James, B ; Preisig, Martin ; Rietschel, Marcella ; Schaefer, Catherine ; Schulze, Thomas, G ; Smoller, Jordan, W ; Stefansson, Kari ; Tiemeier, Henning ; Uher, Rudolf ; Völzke, Henry ; Weissman, Myrna, M ; Werge, Thomas ; Lewis, Cathryn, M ; Levinson, Douglas, F ; Breen, Gerome ; Børglum, Anders, D ; Sullivan, Patrick, F ; Räikkönen, Katri ; Binder, Elisabeth, B ; Max Planck Institute of Psychiatry ; Max-Planck-Gesellschaft ; Helmholtz Zentrum München (HMGU) ; Oslo University Hospital Oslo ; Adelphi ; Institut du Cerveau = Paris Brain Institute (ICM) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 2041-1723, 2019 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2019 |
Medientyp: | academicJournal |
DOI: | 10.1038/s41467-019-10461-0 |
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