A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt.
Public Library of Science (PLoS) ; //dx.doi.org/10.1371/journal.pone.0147928 ; PLoS One, 2016
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Zugriff:
The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. Seroprevalence by age was used in a catalytic model to determine the force of infection. Meningococcal serogroup A IgG antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. The geometric mean concentration (GMC) was highest in Ghana (9.09 μg/mL [95% CI 8.29, 9.97]) and lowest in Ethiopia (1.43 μg/mL [95% CI 1.31, 1.57]) on the margins of the belt. The force of infection was lowest in Ethiopia (λ = 0.028). Variables associated with a concentration above the putative protective level of 2 μg/mL were age, urban residence and a history of recent vaccination with a meningococcal vaccine. Prior to vaccination with the serogroup A meningococcal conjugate vaccine, meningococcal serogroup A IgG antibody concentrations were high across the African meningitis belt and yet the region remained susceptible to epidemics. ; The work described in this paper was supported by grants to the MenAfriCar Consortium from the Wellcome Trust (grant no. 086546/Z/08/Z and the Bill and Melinda Gates Foundation (grant no 51251). ; This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pone.0147928
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A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt.
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Autor/in / Beteiligte Person: | Manigart, Olivier ; Trotter, Caroline ; Findlow, Helen ; Assefa, Abraham ; Mihret, Wude ; Moti Demisse, Tesfaye ; Yeshitela, Biruk ; Osei, Isaac ; Hodgson, Abraham ; Quaye, Stephen Laryea ; Sow, Samba ; Coulibaly, Mamadou ; Diallo, Kanny ; Traore, Awa ; Collard, Jean-Marc ; Moustapha Boukary, Rahamatou ; Djermakoye, Oumarou ; Mahamane, Ali Elhaji ; Jusot, Jean-François ; Sokhna, Cheikh ; Alavo, Serge ; Doucoure, Souleymane ; Ba, El Hadj ; Dieng, Mariétou ; Diallo, Aldiouma ; Daugla, Doumagoum Moto ; Omotara, Babatunji ; Chandramohan, Daniel ; Hassan-King, Musa ; Nascimento, Maria ; Woukeu, Arouna ; Borrow, Ray ; Stuart, James M ; Greenwood, Brian |
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Veröffentlichung: | Public Library of Science (PLoS) ; //dx.doi.org/10.1371/journal.pone.0147928 ; PLoS One, 2016 |
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