Seroprevalence of anti-SARS-CoV-2 antibodies in Senegal: a national population-based cross-sectional survey, between October and November 2020
In: ISSN: 2772-7076 ; IJID Regions ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03752584 ; IJID Regions, 2022, 2022
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Posté le 17 septembre 2021. ; International audience ; ObjectivesA nationwide cross-sectional epidemiological survey was conducted to capture the true extent of coronavirus disease 2019 (COVID-19) exposure in Senegal.MethodsMulti-stage random cluster sampling of households was performed between October and November 2020, at the end of the first wave of COVID-19 transmission. Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies were screened using three distinct ELISA assays. Adjusted prevalence rates for the survey design were calculated for each test separately, and thereafter combined. Crude and adjusted prevalence rates based on test performance were estimated to assess the seroprevalence. As some samples were collected in high malaria endemic areas, the relationship between SARS-CoV-2 seroreactivity and antimalarial humoral immunity was also investigated.ResultsOf the 1463 participants included in this study, 58.8% were female and 41.2% were male; their mean age was 29.2 years (range 0.20–84.8.0 years). The national seroprevalence was estimated at 28.4% (95% confidence interval 26.1–30.8%). There was substantial regional variability. All age groups were impacted, and the prevalence of SARS-CoV-2 was comparable in the symptomatic and asymptomatic groups. An estimated 4 744 392 (95% confidence interval 4 360 164–5 145 327) were potentially infected with SARS-CoV-2 in Senegal, while 16 089 COVID-19 RT-PCR laboratory-confirmed cases were reported by the national surveillance. No correlation was found between SARS-CoV-2 and Plasmodium seroreactivity.ConclusionsThese results provide a better estimate of SARS-CoV-2 dissemination in the Senegalese population. Preventive and control measures need to be reinforced in the country and especially in the south border regions.
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Seroprevalence of anti-SARS-CoV-2 antibodies in Senegal: a national population-based cross-sectional survey, between October and November 2020
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Autor/in / Beteiligte Person: | Talla, Cheikh ; Loucoubar, Cheikh ; Roka, Jerlie Loko ; Barry, Mamadou ; Ndiaye, Seynabou ; Diarra, Maryam ; Thiam, Mareme Seye ; Faye, Oumar ; Dia, Moussa ; Diop, Mamadou ; Ndiaye, Oumar ; Tall, Adama ; Faye, Rokhaya ; Mbow, Adji Astou ; Diouf, Babacar ; Diallo, Jean Pierre ; Keita, Ibrahima Mamby ; Ndiaye, Mamadou ; Woudenberg, Tom ; White, Michael ; Ting, Jim ; Diagne, Cheikh Tidiane ; Pasi, Omer ; Diop, Boly ; Sall, Amadou ; Vigan‑womas, Inès ; Faye, Ousmane ; Institut Pasteur de Dakar ; Réseau International des Instituts Pasteur (RIIP) ; Centers for Disease Control and Prevention Atlanta (CDC) ; Centers for Disease Control and Prevention ; Ministère de la Santé et de l'Action sociale (Sénégal) (MSAS) ; Malaria : parasites et hôtes - Malaria : parasites and hosts ; Institut Pasteur Paris (IP) ; This work was supported by the US Centers for Disease Control and Prevention (CDC), the Senegalese Ministry of Health, the Senegalese National Agency for Statistics and Demography (ANSD), the WHO Unity Program, and the COVID-19 Task-force of the International Pasteur Institute Network (IPIN, REPAIR project). |
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Zeitschrift: | ISSN: 2772-7076 ; IJID Regions ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03752584 ; IJID Regions, 2022, 2022 |
Veröffentlichung: | HAL CCSD, 2022 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.ijregi.2022.02.007 |
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