Sağlıklı çocuklarda plasma serbest karnitin düzeyleri

Ouml;zy;uuml;rek AR, Akıs;uuml; M, Demir N, Coşkun Ş, K;uuml;lt;uuml;rsay N, H;uuml;seyinov A, -Arcasoy M. (Department of Pediatrics, Ege University Faculty of Medicine, İzmir, Turkey). Plasma free carnitine levels in healthy children. ;Ccedil;ocuk Sağlığı ve Hastalıkları Dergisi 1997; 40: 47-52. Carnitine (P-hydroxy-y-N-trimethylaminobutyrate) is a crucial molecule for fatty acid p oxydation since it plays a role in the transport of long-chain fatty acids through inner mitochondrial membranes. In order to diagnose metabolic disorders due to carnitine deficiency, it is necessary to know the normal reference carnitine levels in a given population for different age and sex groups. This study was planned to investigate the plasma free carnitine levels in 80 healthy infants and preschool children (49 male, 31 female) between the ages of one month and six years. The mean free carnitine level was 43.37 ;plusmn; 13.42 umol/L overall. Infants between one and six months in age had a mean level of 42.89 ;plusmn; 12.68 umol/L, while seven-to 24-month children and two- to six-year old preschool children had levels of 43.22 ;plusmn;15.81 umol/L and 45.60 ;plusmn;14.35 umol/L, respectively (p;gt;0.05). When comparing male and female subgroups for each age group no significant difference was found (p;gt;0.05). Therefore, it was concluded that plasma free carnitine levels are independent of gender, reach normal levels within one to six months and remain unchanged throughout the first six years of life. ; Karnitin (p-hidroksi-Y-N-trimetilaminobutirat), uzun zincirli yağ asitlerini mitokondri iç membranından matrikse taşıyarak beta oksidasyonun gerçekleşmesinde çok önemli rol oynayan bir moleküldür. Karnitin eksikliğine bağlı kalıtsal metabolik hastalıklardan şüphe edilen çocukları tanımlayabilmek için, populasyonda yaş ve cinsiyete göre referans değerleri ortaya koymak gereklidir. Bu amaçla çalışmada metabolik olarak sağlıklı, yaşları 1 ay - 6 yıl arasında değişen, 49'u erkek, 31'i kız toplam 80 çocukta plasma serbest karnitin ...