Assessment of the Risk of Exotic Zika Virus Strain Transmission by Aedes aegypti and Culex quinquefasciatus from Senegal Compared to a Native Strain
In: ISSN: 2414-6366 ; Tropical Medicine and Infectious Disease ; https://hal.science/hal-04489312 ; Tropical Medicine and Infectious Disease, 2023, 2023
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Zugriff:
International audience ; Zika virus (ZIKV) shows an enigmatic epidemiological profile in Africa. Despite its frequent detection in mosquitoes, few human cases have been reported. This could be due to the low infectious potential or low virulence of African ZIKV lineages. This study sought to assess the susceptibility of A. aegypti and C. quinquefasciatus to ZIKV strains from Senegal, Brazil, and New Caledonia. Vertical transmission was also investigated. Whole bodies, legs/wings and saliva samples were tested for ZIKV by real-time PCR to estimate infection, dissemination and transmission rates as well as the infection rate in the progeny of infected female A. aegypti. For A. aegypti, the Senegalese strain showed at 15 days post-exposure (dpe) a significantly higher infection rate (52.43%) than the Brazilian (10%) and New Caledonian (0%) strains. The Brazilian and Senegalese strains were disseminated but not detected in saliva. No A. aegypti offspring from females infected with Senegalese and Brazilian ZIKV strains tested positive. No infection was recorded for C. quinquefasciatus. We observed the incompetence of Senegalese A. aegypti to transmit ZIKV and the C. quinquefasciatus were completely refractory. The effect of freezing ZIKV had no significant impact on the vector competence of Aedes aegypti from Senegal, and vertical transmission was not reported in this study.
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Assessment of the Risk of Exotic Zika Virus Strain Transmission by Aedes aegypti and Culex quinquefasciatus from Senegal Compared to a Native Strain
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Autor/in / Beteiligte Person: | Gaye, Alioune ; Fall, Cheikh ; Faye, Oumar ; Dupont-Rouzeyrol, Myrielle ; Ndiaye, El Hadji ; Diallo, Diawo ; de Andrade Zanotto, Paolo Marinho ; Dia, Ibrahima ; Weaver, Scott, C ; Diallo, Mawlouth ; Institut Pasteur de Dakar ; Réseau International des Instituts Pasteur (RIIP) ; Dengue et Arbovirose (URE-DA) ; Institut Pasteur de Nouvelle-Calédonie ; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) ; Universidade de São Paulo = University of São Paulo (USP) ; University of Texas Medical Branch at Galveston ; This work was funded by ACIP A-15-2014 Zikae Project, the European Union: H2020-SC1-2016-2017/H2020-SC1-2016-RTD-Zika in a framework of the project entitled “A Global Alliance for Zika Virus Control and Prevention (ZIKAlliance)” and the NIH/NIAID: U01 AI151801, in a framework of West African Center for Emerging Infectious Diseases. ; European Project: 732432,H2020-SC1-2016-RTD,ZIKAVAX(2016) ; European Project: 734548,ZIKAlliance(2016) |
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Zeitschrift: | ISSN: 2414-6366 ; Tropical Medicine and Infectious Disease ; https://hal.science/hal-04489312 ; Tropical Medicine and Infectious Disease, 2023, 2023 |
Veröffentlichung: | HAL CCSD ; MDPI, 2023 |
Medientyp: | academicJournal |
DOI: | 10.3390/tropicalmed8020130 |
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