Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains
In: ISSN: 2041-1723, 2021
Online
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International audience ; Abstract The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.
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Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains
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Autor/in / Beteiligte Person: | Aubry, Fabien ; Jacobs, Sofie ; Darmuzey, Maïlis ; Lequime, Sebastian ; Delang, Leen ; Fontaine, Albin ; Jupatanakul, Natapong ; Miot, Elliott ; Dabo, Stéphanie ; Manet, Caroline ; Montagutelli, Xavier ; Baidaliuk, Artem ; Gámbaro, Fabiana ; Simon-Loriere, Etienne ; Gilsoul, Maxime ; Romero-Vivas, Claudia ; Cao-Lormeau, Van-Mai ; Jarman, Richard ; Diagne, Cheikh ; Faye, Oumar ; Faye, Ousmane ; Sall, Amadou ; Neyts, Johan ; Nguyen, Laurent ; Kaptein, Suzanne ; Lambrechts, Louis, A ; Interactions Virus-Insectes - Insect-Virus Interactions (IVI) ; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) ; Vecteurs - Infections tropicales et méditerranéennes (VITROME) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA) ; Institut de Recherche Biomédicale des Armées Antenne Marseille (IRBA) ; Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille) ; ANR-16-CE35-0004,MOSQUIBIOTA,Contribution de la diversité bactérienne intestinale à la capacité vectorielle d'Aedes aegypti(2016) ; ANR-18-CE35-0003,BAKOUMBA,Dissection de la base génétique d'un phénotype naturel de résistance à la dengue chez le moustique Aedes aegypti(2018) |
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Zeitschrift: | ISSN: 2041-1723, 2021 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2021 |
Medientyp: | academicJournal |
DOI: | 10.1038/s41467-021-21199-z |
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