Emerging and re-emerging KPC-producing hypervirulent Pseudomonas aeruginosa ST697 and ST463 between 2010 and 2021 ...
Taylor & Francis, 2022
academicJournal
Zugriff:
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has been a major threat to human health due to its increased morbidity and mortality in clinical settings. Carbapenemase genes are less frequently found in CRPA compared with carbapenem-resistant Enterobacterales , of which carbapenemase producers are common. In this study, we identified 11 bla KPC-2 -harbouring P. aeruginosa isolates from 139 carbapenemase-insensitive P . aeruginosa isolates collected between 2010 and 2021 in a tertiary hospital in China. Nine isolates belonged to ST697, while the other two were ST463. The antibiotic susceptibility testing showed that all the isolates were multidrug resistant, including resistance to imipenem, meropenem, ceftazidime, and tigecycline. Patients with Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing P. aeruginosa infections were mostly associated with complicated diseases and prolonged hospital stay, with 30% deterioration. The whole-genome sequencing analysis showed that these isolates carried multiple ...
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Emerging and re-emerging KPC-producing hypervirulent Pseudomonas aeruginosa ST697 and ST463 between 2010 and 2021 ...
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Autor/in / Beteiligte Person: | Zhang, Biying ; Xu, Xun ; Song, Xiaomei ; Wen, Yicheng ; Zhu, Zhichen ; Lv, Jingnan ; Xie, Xiaofang ; Chen, Liang ; Tang, Yi-Wei ; Du, Hong |
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Veröffentlichung: | Taylor & Francis, 2022 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.21435757 |
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