Comparing Treatment Outcomes of Antiretroviral Therapy in HIV-1 and HIV-2 Infected Patients, in Bamako, Mali.
In: Current findings of infectious diseases, Vol. 2018, no.1, p. RD-INF-10003 [1-8] (2018, 2018
Online
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Zugriff:
BACKGROUND: HIV-2 leads to a less-severe disease than HIV-1 but is known to be resistant to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). We goaled to evaluate the clinical and biological outcomes of HIV-1 and HIV-2 infected-patients under Antiretroviral Therapy (ART) that do not include NNRTIs. METHODS: This is a case-control study of 100 participants (half in each group) to measure the frequency of clinical and biological adverse effects, and disease outcome at 6 and 12 months of treatment (M6 and M12) We included. RESULTS: Opportunistic infections were more frequent in HIV-1 infected patients with 82% when compared to HIV-2, 68%. However, the prevalence of treatment adverse events was slightly higher in HIV-2 infected patients. The average increase of CD4 cell count at M6 of treatment was 139.93 and 159.41 cells/mm3, for HIV-2 and HIV-1 groups respectively, and at 153 and 217 cells/mm3, at M12 for HIV-2 and HIV-1 respectively. A total of nine HIV-2 and six HIV-1 deaths were reported during the study. CONCLUSION: This study has shown that ART regimens that do not include NNRTIs are effective equally in the treatment of HIV-1 and HIV-2 infections. Nevertheless, we recommend regular and continuous laboratory monitoring for all HIV treated patients.
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Comparing Treatment Outcomes of Antiretroviral Therapy in HIV-1 and HIV-2 Infected Patients, in Bamako, Mali.
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Autor/in / Beteiligte Person: | Oumar, Aboubacar Alassane ; Cissoko, Yacouba ; Konaté, Issa ; Kane, Adam ; Dembélé, Jean Paul ; Cissé, Mamadou ; Murphy, Robert Leo ; Yombi, Jean Cyr ; Seydi, Moussa ; Dao, Sounkalo ; Maiga, Mamoudou ; UCL - SSS/IREC/SLUC - Pôle St.-Luc ; UCL - (SLuc) Service de médecine interne générale |
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Zeitschrift: | Current findings of infectious diseases, Vol. 2018, no.1, p. RD-INF-10003 [1-8] (2018, 2018 |
Veröffentlichung: | ReDelve International Publications LLC, 2018 |
Medientyp: | academicJournal |
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