First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
In: Life; Volume 13; Issue 3; Pages: 847, 2023
academicJournal
Zugriff:
Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn pairs, although newborns are considered vitK deficient and with sterile gut. Methods: We collected venous blood from 45 healthy mothers with uncomplicated term pregnancies and umbilical cord blood from their newborns at birth. The concentrations of total SCFAs and hepatic/extra-hepatic vitK-dependent proteins (VKDPs), as proxies of vitK status were assayed: undercarboxylated and total matrix Gla protein (ucMGP and tMGP), undercarboxylated osteocalcin (ucOC), undercarboxylated Gla-rich protein (ucGRP), and protein induced by vitK absence II (PIVKA-II). Results: We found significantly higher ucOC (18.6-fold), ucMGP (9.2-fold), and PIVKA-II (5.6-fold) levels in newborns, while tMGP (5.1-fold) and SCFAs (2.4-fold) were higher in mothers, and ucGRP was insignificantly modified. In mother–newborn pairs, only ucGRP (r = 0.746, p < 0.01) and SCFAs (r = 0.428, p = 0.01) levels were correlated. Conclusions: We report for the first time the presence of SCFAs in humans at birth, probably transferred through the placenta to the fetus. The increased circulating undercarboxylated VKDPSs in newborns revealed a higher vitamin K deficiency at the extrahepatic level compared to liver VKDPs.
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First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth
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Autor/in / Beteiligte Person: | Ilyés, Tamás ; Pop, Marius ; Surcel, Mihai ; Pop, Daria M. ; Rusu, Răzvan ; Silaghi, Ciprian N. ; Zaharie, Gabriela C. ; Crăciun, Alexandra M. |
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Zeitschrift: | Life; Volume 13; Issue 3; Pages: 847, 2023 |
Veröffentlichung: | Multidisciplinary Digital Publishing Institute, 2023 |
Medientyp: | academicJournal |
DOI: | 10.3390/life13030847 |
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