Haematological consequences of acute uncomplicated falciparum malaria : a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Mansoor, Rashid ; Commons, Robert J. ; et al.

Uppsala universitet, Internationell barnhälsa och nutrition ; Uppsala universitet, Centrum för klinisk forskning i Sörmland (CKFD) ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;UCL, Dept Stat Sci, London, England. ; WorldWide Antimalarial Resistance Network WWARN, Darwin, NT, Australia.;Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.;Ballarat Hlth Serv, Internal Med Serv, Ballarat, Vic, Australia. ; Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia. ; Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana. ; Uganda Malaria Surveillance Project, Kampala, Uganda.;Malaria Consortium, London, England. ; Univ Khartoum, Fac Med, Khartoum, Sudan. ; Univ Ghana Med Sch, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana. ; Navrongo Hlth Res Ctr, Navrongo, Ghana. ; Columbia Univ, ICAP Mailman Sch Publ Hlth, New York, NY USA. ; MENTOR Initiat, Burns House,Harlands Rd, Haywards Heath, W Sussex, England. ; Univ Cape Town, Dept Med, Div Clin Pharmacol, Cape Town, South Africa.;Univ Cape Town, WorldWide Antimalarial Resistance Network WWARN, Cape Town, South Africa. ; Natl Inst Malaria Res, New Delhi, India. ; Univ Calif San Francisco, Makerere Univ Univ Calif San Francisco Res Collab, San Francisco, CA 94143 USA.;Infect Dis Res Collaborat, Kampala, Uganda. ; Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand. ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England. ; Eijkman Inst Mol Biol, Jakarta, Indonesia. ; Minist Hlth, Kampala, Uganda.;World Hlth Org, Lusaka, Zambia. ; Agence Natl Rech Sur Sida ANRS, Paris, France.;Unite Epidemiol Intervent Ctr Muraz, Bobo Dioulasso, Burkina Faso.;Inst Francophone Med Trop, Viangchan, Laos. ; Inst Rech Dev IRD, UMR 198, Marseille, France.;Org Coordinat Lutte Endemies Afrique Cent OCEAC, Lab Rech Paludisme, Yaounde, Cameroon. ; Ctr Invest Saude Manhica CISM, Maputo, Mozambique.;Hosp Clin Univ Barcelona, ISGlobal, Barcelona, Spain.;ICREA, Barcelona 08010, Spain. ; Epicentre, Paris, France. ; Queen Elizabeth Univ Hosp, Infect Dis Unit, Glasgow, Lanark, Scotland. ; US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. ; Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. ; Novartis, Basel, Switzerland. ; Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Njimegen, Netherlands.;London Sch Hyg & Trop Med, Dept Infect & Immun, London, England. ; Inst Rech Dev IRD, Dakar, Senegal. ; Uganda Malaria Surveillance Project, Kampala, Uganda. ; Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.;Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand. ; Inst Rech Dev IRD, Mother & Child Hlth Trop Res Unit, Cotonou, Benin.;Univ Paris, Paris, France. ; London Sch Hyg & Trop Med, MRC Unit Gambia, Banjul, Gambia. ; Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok, Thailand. ; Manipal Univ Coll Malaysia, Fac Med, Dept Physiol, Melaka, Malaysia. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia. ; CDC Div Parasit Dis & Malaria, CDC Atlanta, Atlanta, GA USA.;Kenya Govt Med Res Ctr, Nairobi, Kenya. ; Univ Sci Tech & Technol, Fac Pharm, Malaria Res & Training Ctr, Bamako, Mali. ; Univ Calif San Francisco, Dept Med, San Francisco, CA USA. ; London Sch Trop Med & Hyg, Dept Infect Biol, London, England. ; Med Malaria Venture, Geneva, Switzerland. ; France GSK Vaccines, Epictr, Rixensart, Belgium. ; Epicentre, Montpellier, France.;Univ Montpellier, TransVIHMI Inst Rech Dev, IRD MI 233, Montpellier, France.;Univ Montpellier, Inst Natl Sante & Rech Med, INSERM U1175, Montpellier, France.;Universit Montpellier, Montpellier, France. ; Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria. ; Inst Rech Dev IRD, Mother & Child Hlth Trop Res Unit, Cotonou, Benin.;Limoges Univ Hosp, Infect Dis & Trop Med Dept, Limoges, France. ; Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland. ; Epicentre, Paris, France.;Univ Southampton, Sch Hlth Sci, Southampton, Hants, England. ; US Army Directorate Armed Forces, Res Inst Med Sci AFRIMS, Bangkok, Thailand. ; Univ Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal. ; Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland. ; Nangarhar Univ, Med Fac, Jalalabad, Afghanistan.;MORU Trop Hlth Network, Bangkok, Thailand. ; Minist Hlth, Natl Malaria Control Program, Monrovia, Liberia. ; Ctr Invest Saude Manhica, Manhica, Mozambique.;Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona, Spain. ; London Sch Hyg & Trop Med, Dept Dis Control, London, England. ; Johns Hopkins Sch Med, Baltimore, MD USA. ; Univ Basel, Basel, Switzerland.;Swiss Trop & Publ Hlth Inst, Basel, Switzerland. ; Swiss Trop Inst & Publ Hlth Inst, Basel, Switzerland.;Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, England.;Univ Liverpool, Inst Infect Vet & Ecol Sci, Ronald Ross Bldg,West Derby St, Liverpool L69 7BE, Merseyside, England. ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Green Templeton Coll, Oxford, England. ; Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.;Ctr Dis Control & Prevent, Presidents Malaria Initiat, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. ; Natl Inst Med Res NIMR, Dar Es Salaam, Tanzania.;Monash Univ, Fac Pharmaceut Sci, Melbourne, Vic, Australia.;Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA. ; Ctr Clin Res, Kenya Med Res Inst, Nairobi, Kenya. ; Columbia Univ Med Ctr, New York, NY USA. ; Acad Med Ctr, Amsterdam, Netherlands. ; Catholic Univ Hlth & Allied Sci, Mwanza, Tanzania. ; Makerere Univ, Coll Hlth Sci, Kampala, Uganda. ; Univ Basel, Basel, Switzerland.;Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Qual & Equ Healthcare, Kigali, Rwanda. ; Univ Bamako, Fac Med Pharm & Dent, Malaria Res & Training Ctr, Dept Epidemiol Parasitol Dis, Bamako, Mali. ; Unit Rech Clin Nanoro, Ouagadougou, Burkina Faso. ; Drugs Neglected Dis Initiat DNDi, Geneva, Switzerland. ; Projecto Saude Bandim, Bissau, Guinea Bissau.;IRS Univ Southern Denmark, Kolding Hosp, Dept Paediat, Aarhus, Denmark. ; Ctr Rech Med Lambarene, Lambarene, Gabon.;Univ Tubingen, Inst Trop Med, Tubingen, Germany. ; Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England.;Malawi Liverpool Wellcome Clin Res Programme, Blantyre, Malawi. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia.;Papua New Guinea Inst Med Res, Madang, Papua N Guinea. ; Ctr Rech Med Lambarene, Lambarene, Gabon.;Med Univ Vienna, Dept Med, Div Infect Dis & Trop Med, Vienna, Austria. ; Univ Bamako, Fac Med Pharm & Odontostomatol, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali. ; Lao Oxford Mahosot Hosp Wellcome Trust Res Unit L, Viangchan, Laos.;Univ Hlth Sci, Inst Res & Educ Dev IRED, Minist Hlth, Viangchan, Laos. ; Univ Yaounde, Biotechnol Ctr, Yaounde, Cameroon. ; Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand. ; Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire. ; Inst Pasteur, Malaria Genet & Resistance Unit, Paris, France. ; Charite Univ Med Berlin, Inst Trop Med & Int Hlth, Berlin, Germany. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia.;Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA, Australia. ; Ruprecht Karls Univ Heidelberg, Inst Global Hlth, Med Sch, Heidelberg, Germany. ; Ctr Rech Entomol Cotonou, Cotonou, Benin. ; Univ Thies, Dept Parasitol, Res & Training Unit Hlth Sci, Thies, Senegal. ; Mahosot Hosp, Lao Oxford Mahosot Hosp Wellcome Res Unit, Microbiol Lab, Viangchan, Laos. ; Karolinska Inst, Dept Med, Infect Dis Unit, Malaria Res, Stockholm, Sweden.;Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania. ; Inst Rech Sci Sante IRSS, Bobo Dioulasso, Burkina Faso. ; Malaria Res Initiat Bandarban, Vienna, Austria. ; Kenya Govt Med Res Ctr, Ctr Clin Res, US Army Med Res Unit, Kisumu, Kenya. ; Ladoke Akintola Univ Technol, Osogbo, Nigeria. ; CIDEIM Int Ctr Med Res & Training, Cali, Colombia. ; Inst Rech Sci Sante IRSS, Bobo Dioulasso, Burkina Faso.;Inst Rech Sci Sante, Unite Rech Paludisme & Malad Tropicales Negligees, Bobo Dioulasso, Burkina Faso. ; Kintampo Hlth Res Ctr, Kintampo, Ghana. ; Ipca Labs Ltd, Med Affairs & Clin Res, Mumbai, Maharashtra, India. ; Inst Pasteur, Malariol Dept, Abidjan, Cote Ivoire. ; Epicentre, Paris, France.;Inst Pasteur Cambodge, Unite Epidemiol, Phnom Penh, France. ; Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. ; Univ Med Ctr Hamburg Eppendorf, Dept Trop Med, Dept Med, Bernhard Nocht Inst Trop Med, Hamburg, Germany. ; Univ Western Australia, Med Sch, Perth, WA, Australia.;UCL, Div Infect & Immun, NIHR Mucosal Pathogens Res Unit, London, England. ; Univ Yaounde, Ctr Hosp Univ Yaounde, Yaounde, Cameroon. ; Grp Rech Act Sante GRAS, Ouagadougou, Burkina Faso. ; Myanmar Oxford Clin Res Unit MOCRU, Yangon, Myanmar.;Med Sans Frontieres Holland, Yangon, Myanmar. ; Inst Rech Sci Sante IRSS, Nanoro, Burkina Faso. ; Infect Dis Res Collaborat, Kampala, Uganda.;London Sch Hyg & Trop Med, Dept Clin Res, London, England. ; Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.;Med Univ Vienna, Dept Lab Med, Div Clin Microbiol, Vienna, Austria. ; Drugs Neglected Dis Initiat, Geneva, Switzerland. ; Univ Indonesia, Fac Med, Dept Parasitol, Jakarta, Indonesia. ; Med Sans Frontieres, London, England. ; World Hlth Org, Reg Off Africa, Brazzaville, Rep Congo. ; Mahidol Oxford Trop Med Res Unit MORU, Mahidol Univ, Bangkok, Thailand. ; UNOPS RBM Partnership End Malaria, Geneva, Switzerland. ; Ctr Dis Control, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA. ; Inst Rech Sci Sante IRSS, Nanoro, Burkina Faso.;Ctr Muraz, Unite Rech Paludisme & Malad Trop Negligence, Bobo Dioulasso, Burkina Faso. ; Minist Hlth, Natl Inst Hlth Res & Dev NIHRD, Jakarta, Indonesia. ; Indepth Network, Projecto Saude Bandim, Bissau, Guinea Bissau.;Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden. ; Ctr Muraz, Unite Rech Paludisme & Malad Trop Negligence, Bobo Dioulasso, Burkina Faso.;Inst Rech Sci Sante, Unite Rech Clin Nanoro, Nanoro, Burkina Faso. ; Alfasigma, Rome, Italy. ; Shoklo Malaria Res Unit, Mae Sot, Thailand.;Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Div Infect Dis, Amsterdam, Netherlands. ; MRC Labs, Farafenni Field Stn, Serrekunda, Gambia.;Mahidol Univ, Mahidol Oxford Univ Res Unit MORU, Bangkok, Thailand. ; Univ Liverpool Liverpool Sch Trop Med, Trop Dis Biol, Liverpool, Merseyside, England. ; Kenya Govt Med Res Ctr, Nairobi, Kenya. ; Mahidol Univ, Fac Trop Med, Bangkok, Thailand. ; Fac Pharmaceut & Biol Sci, Dept Parasitol & Mycol, Abidjan, Cote Ivoire.;Univ Cocody, Abidjan, Cote Ivoire. ; Uganda Minist Hlth, Uganda Malaria Surveillance Project, Kampala, Uganda. ; Inst Rech Sci Sante IRSS, Ouagadougou, Burkina Faso. ; Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;WorldWide Antimalarial Resistance Network WWARN, Melbourne, Vic, Australia. ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Charles Darwin Univ, Menzies Sch Hlth Res, Trop Hlth Div, Darwin, NT, Australia. ; London Sch Hyg & Trop Med, London, England. ; Springer Nature ; Oxford Univ Clin Res Unit OUCRU, Wellcome Trust Major Overseas Programme Mop, Ho Chi Minh City, Vietnam., 2022

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Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall >= 25% at day 3 and day 7. Results A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0-19.7 g/dL) in Africa, 11.6 g/dL (range 5.0-20.0 g/dL) in Asia and 12.3 g/dL (range 6.9-17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to >= 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed ...

Titel:	Haematological consequences of acute uncomplicated falciparum malaria : a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data
Autor/in / Beteiligte Person:	Mansoor, Rashid ; Commons, Robert J. ; Douglas, Nicholas M. ; Abuaku, Benjamin ; Achan, Jane ; Adam, Ishag ; Adjei, George O. ; Adjuik, Martin ; Alemayehu, Bereket H. ; Allan, Richard ; Allen, Elizabeth N. ; Anvikar, Anupkumar R. ; Arinaitwe, Emmanuel ; Ashley, Elizabeth A. ; Ashurst, Hazel ; Asih, Puji B. S. ; Bakyaita, Nathan ; Barennes, Hubert ; Barnes, Karen, I ; Basco, Leonardo ; Bassat, Quique ; Baudin, Elisabeth ; Bell, David J. ; Bethell, Delia ; Bjorkman, Anders ; Boulton, Caroline ; Bousema, Teun ; Brasseur, Philippe ; Bukirwa, Hasifa ; Burrow, Rebekah ; Carrara, Verena, I ; Cot, Michel ; D'Alessandro, Umberto ; Das, Debashish ; Das, Sabyasachi ; Davis, Timothy M. E. ; Desai, Meghna ; Djimde, Abdoulaye A. ; Dondorp, Arjen M. ; Dorsey, Grant ; Drakeley, Chris J. ; Duparc, Stephan ; Espie, Emmanuelle ; Etard, Jean-Francois ; Falade, Catherine ; Faucher, Jean Francois ; Filler, Scott ; Fogg, Carole ; Fukuda, Mark ; Gaye, Oumar ; Genton, Blaise ; Rahim, Awab Ghulam ; Gilayeneh, Julius ; Gonzalez, Raquel ; Grais, Rebecca F. ; Grandesso, Francesco ; Greenwood, Brian ; Grivoyannis, Anastasia ; Hatz, Christoph ; Hodel, Eva Maria ; Humphreys, Georgina S. ; Hwang, Jimee ; Ishengoma, Deus ; Juma, Elizabeth ; Kachur, S. Patrick ; Kager, Piet A. ; Kamugisha, Erasmus ; Kamya, Moses R. ; Karema, Corine ; Kayentao, Kassoum ; Kazienga, Adama ; Kiechel, Jean-Rene ; Kofoed, Poul-Erik ; Koram, Kwadwo ; Kremsner, Peter G. ; Lalloo, David G. ; Laman, Moses ; Lee, Sue J. ; Lell, Bertrand ; Maiga, Amelia W. ; Mårtensson, Andreas ; Mayxay, Mayfong ; Mbacham, Wilfred ; McGready, Rose ; Menan, Herve ; Menard, Didier ; Mockenhaupt, Frank ; Moore, Brioni R. ; Muller, Olaf ; Nahum, Alain ; Ndiaye, Jean-Louis ; Newton, Paul N. ; Ngasala, Billy E. ; Nikiema, Frederic ; Nji, Akindeh M. ; Noedl, Harald ; Nosten, Francois ; Ogutu, Bernhards R. ; Ojurongbe, Olusola ; Osorio, Lyda ; Ouedraogo, Jean-Bosco ; Owusu-Agyei, Seth ; Pareek, Anil ; Penali, Louis K. ; Piola, Patrice ; Plucinski, Mateusz ; Premji, Zul ; Ramharter, Michael ; Richmond, Caitlin L. ; Rombo, Lars ; Rosenthal, Philip J. ; Salman, Sam ; Same-Ekobo, Albert ; Sibley, Carol ; Sirima, Sodiomon B. ; Smithuis, Frank M. ; Some, Fabrice A. ; Staedke, Sarah G. ; Starzengruber, Peter ; Strub-Wourgaft, Nathalie ; Sutanto, Inge ; Swarthout, Todd D. ; Syafruddin, Din ; Talisuna, Ambrose O. ; Taylor, Walter R. ; Temu, Emmanuel A. ; Thwing, Julie, I ; Tinto, Halidou ; Tjitra, Emiliana ; Toure, Offianan A. ; Tran, T. Hien ; Ursing, Johan ; Valea, Innocent ; Valentini, Giovanni ; van Vugt, Michele ; von Seidlein, Lorenz ; Ward, Stephen A. ; Were, Vincent ; White, Nicholas J. ; Woodrow, Charles J. ; Yavo, William ; Yeka, Adoke ; Zongo, Issaka ; Simpson, Julie A. ; Guerin, Philippe J. ; Stepniewska, Kasia ; Price, Ric N. ; Roper, Cally
Link:	Volltext https://doi.org/10.1186/s12916-022-02265-9
Veröffentlichung:	Uppsala universitet, Internationell barnhälsa och nutrition ; Uppsala universitet, Centrum för klinisk forskning i Sörmland (CKFD) ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;UCL, Dept Stat Sci, London, England. ; WorldWide Antimalarial Resistance Network WWARN, Darwin, NT, Australia.;Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.;Ballarat Hlth Serv, Internal Med Serv, Ballarat, Vic, Australia. ; Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia. ; Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana. ; Uganda Malaria Surveillance Project, Kampala, Uganda.;Malaria Consortium, London, England. ; Univ Khartoum, Fac Med, Khartoum, Sudan. ; Univ Ghana Med Sch, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana. ; Navrongo Hlth Res Ctr, Navrongo, Ghana. ; Columbia Univ, ICAP Mailman Sch Publ Hlth, New York, NY USA. ; MENTOR Initiat, Burns House,Harlands Rd, Haywards Heath, W Sussex, England. ; Univ Cape Town, Dept Med, Div Clin Pharmacol, Cape Town, South Africa.;Univ Cape Town, WorldWide Antimalarial Resistance Network WWARN, Cape Town, South Africa. ; Natl Inst Malaria Res, New Delhi, India. ; Univ Calif San Francisco, Makerere Univ Univ Calif San Francisco Res Collab, San Francisco, CA 94143 USA.;Infect Dis Res Collaborat, Kampala, Uganda. ; Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand. ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England. ; Eijkman Inst Mol Biol, Jakarta, Indonesia. ; Minist Hlth, Kampala, Uganda.;World Hlth Org, Lusaka, Zambia. ; Agence Natl Rech Sur Sida ANRS, Paris, France.;Unite Epidemiol Intervent Ctr Muraz, Bobo Dioulasso, Burkina Faso.;Inst Francophone Med Trop, Viangchan, Laos. ; Inst Rech Dev IRD, UMR 198, Marseille, France.;Org Coordinat Lutte Endemies Afrique Cent OCEAC, Lab Rech Paludisme, Yaounde, Cameroon. ; Ctr Invest Saude Manhica CISM, Maputo, Mozambique.;Hosp Clin Univ Barcelona, ISGlobal, Barcelona, Spain.;ICREA, Barcelona 08010, Spain. ; Epicentre, Paris, France. ; Queen Elizabeth Univ Hosp, Infect Dis Unit, Glasgow, Lanark, Scotland. ; US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. ; Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. ; Novartis, Basel, Switzerland. ; Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Njimegen, Netherlands.;London Sch Hyg & Trop Med, Dept Infect & Immun, London, England. ; Inst Rech Dev IRD, Dakar, Senegal. ; Uganda Malaria Surveillance Project, Kampala, Uganda. ; Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.;Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand. ; Inst Rech Dev IRD, Mother & Child Hlth Trop Res Unit, Cotonou, Benin.;Univ Paris, Paris, France. ; London Sch Hyg & Trop Med, MRC Unit Gambia, Banjul, Gambia. ; Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok, Thailand. ; Manipal Univ Coll Malaysia, Fac Med, Dept Physiol, Melaka, Malaysia. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia. ; CDC Div Parasit Dis & Malaria, CDC Atlanta, Atlanta, GA USA.;Kenya Govt Med Res Ctr, Nairobi, Kenya. ; Univ Sci Tech & Technol, Fac Pharm, Malaria Res & Training Ctr, Bamako, Mali. ; Univ Calif San Francisco, Dept Med, San Francisco, CA USA. ; London Sch Trop Med & Hyg, Dept Infect Biol, London, England. ; Med Malaria Venture, Geneva, Switzerland. ; France GSK Vaccines, Epictr, Rixensart, Belgium. ; Epicentre, Montpellier, France.;Univ Montpellier, TransVIHMI Inst Rech Dev, IRD MI 233, Montpellier, France.;Univ Montpellier, Inst Natl Sante & Rech Med, INSERM U1175, Montpellier, France.;Universit Montpellier, Montpellier, France. ; Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria. ; Inst Rech Dev IRD, Mother & Child Hlth Trop Res Unit, Cotonou, Benin.;Limoges Univ Hosp, Infect Dis & Trop Med Dept, Limoges, France. ; Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland. ; Epicentre, Paris, France.;Univ Southampton, Sch Hlth Sci, Southampton, Hants, England. ; US Army Directorate Armed Forces, Res Inst Med Sci AFRIMS, Bangkok, Thailand. ; Univ Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal. ; Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland. ; Nangarhar Univ, Med Fac, Jalalabad, Afghanistan.;MORU Trop Hlth Network, Bangkok, Thailand. ; Minist Hlth, Natl Malaria Control Program, Monrovia, Liberia. ; Ctr Invest Saude Manhica, Manhica, Mozambique.;Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona, Spain. ; London Sch Hyg & Trop Med, Dept Dis Control, London, England. ; Johns Hopkins Sch Med, Baltimore, MD USA. ; Univ Basel, Basel, Switzerland.;Swiss Trop & Publ Hlth Inst, Basel, Switzerland. ; Swiss Trop Inst & Publ Hlth Inst, Basel, Switzerland.;Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, England.;Univ Liverpool, Inst Infect Vet & Ecol Sci, Ronald Ross Bldg,West Derby St, Liverpool L69 7BE, Merseyside, England. ; WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Green Templeton Coll, Oxford, England. ; Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.;Ctr Dis Control & Prevent, Presidents Malaria Initiat, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. ; Natl Inst Med Res NIMR, Dar Es Salaam, Tanzania.;Monash Univ, Fac Pharmaceut Sci, Melbourne, Vic, Australia.;Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA. ; Ctr Clin Res, Kenya Med Res Inst, Nairobi, Kenya. ; Columbia Univ Med Ctr, New York, NY USA. ; Acad Med Ctr, Amsterdam, Netherlands. ; Catholic Univ Hlth & Allied Sci, Mwanza, Tanzania. ; Makerere Univ, Coll Hlth Sci, Kampala, Uganda. ; Univ Basel, Basel, Switzerland.;Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Qual & Equ Healthcare, Kigali, Rwanda. ; Univ Bamako, Fac Med Pharm & Dent, Malaria Res & Training Ctr, Dept Epidemiol Parasitol Dis, Bamako, Mali. ; Unit Rech Clin Nanoro, Ouagadougou, Burkina Faso. ; Drugs Neglected Dis Initiat DNDi, Geneva, Switzerland. ; Projecto Saude Bandim, Bissau, Guinea Bissau.;IRS Univ Southern Denmark, Kolding Hosp, Dept Paediat, Aarhus, Denmark. ; Ctr Rech Med Lambarene, Lambarene, Gabon.;Univ Tubingen, Inst Trop Med, Tubingen, Germany. ; Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England.;Malawi Liverpool Wellcome Clin Res Programme, Blantyre, Malawi. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia.;Papua New Guinea Inst Med Res, Madang, Papua N Guinea. ; Ctr Rech Med Lambarene, Lambarene, Gabon.;Med Univ Vienna, Dept Med, Div Infect Dis & Trop Med, Vienna, Austria. ; Univ Bamako, Fac Med Pharm & Odontostomatol, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali. ; Lao Oxford Mahosot Hosp Wellcome Trust Res Unit L, Viangchan, Laos.;Univ Hlth Sci, Inst Res & Educ Dev IRED, Minist Hlth, Viangchan, Laos. ; Univ Yaounde, Biotechnol Ctr, Yaounde, Cameroon. ; Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand. ; Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire. ; Inst Pasteur, Malaria Genet & Resistance Unit, Paris, France. ; Charite Univ Med Berlin, Inst Trop Med & Int Hlth, Berlin, Germany. ; Univ Western Australia, Fremantle Hosp, Med Sch, Fremantle, WA, Australia.;Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA, Australia. ; Ruprecht Karls Univ Heidelberg, Inst Global Hlth, Med Sch, Heidelberg, Germany. ; Ctr Rech Entomol Cotonou, Cotonou, Benin. ; Univ Thies, Dept Parasitol, Res & Training Unit Hlth Sci, Thies, Senegal. ; Mahosot Hosp, Lao Oxford Mahosot Hosp Wellcome Res Unit, Microbiol Lab, Viangchan, Laos. ; Karolinska Inst, Dept Med, Infect Dis Unit, Malaria Res, Stockholm, Sweden.;Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania. ; Inst Rech Sci Sante IRSS, Bobo Dioulasso, Burkina Faso. ; Malaria Res Initiat Bandarban, Vienna, Austria. ; Kenya Govt Med Res Ctr, Ctr Clin Res, US Army Med Res Unit, Kisumu, Kenya. ; Ladoke Akintola Univ Technol, Osogbo, Nigeria. ; CIDEIM Int Ctr Med Res & Training, Cali, Colombia. ; Inst Rech Sci Sante IRSS, Bobo Dioulasso, Burkina Faso.;Inst Rech Sci Sante, Unite Rech Paludisme & Malad Tropicales Negligees, Bobo Dioulasso, Burkina Faso. ; 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Medientyp:	academicJournal
DOI:	10.1186/s12916-022-02265-9
Schlagwort:	Plasmodium falciparum Artemisinin-based therapy Non-artemisinin-based therapy Antimalarials Haemoglobin Severe anaemia Pooled analysis of individual patient data Infectious Medicine Infektionsmedicin Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi
Sonstiges:	Nachgewiesen in: BASE Sprachen: English Collection: Uppsala University: Publications (DiVA) Document Type: article in journal/newspaper File Description: application/pdf Language: English Rights: info:eu-repo/semantics/openAccess

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