Kinetic characteristics of ductal carcinoma in situ (DCIS) in dynamic breast MRI using computer-assisted analysis
In: Acta Radiologica, Jg. 51 (2010), Heft 9, S. 955-961
academicJournal
Zugriff:
Background: Enhancement characteristics of breast lesions are regarded as a major criterion for their differential diagnosis in dynamic breast MRI (bMRI). However, ductal carcinoma in situ (DCIS) exhibits a highly heterogeneous enhancement pattern when kinetic analysis is performed conventionally by manual placement of region of interest (ROI) and therefore its diagnosis remains challenging. Purpose: To compare enhancement characteristics of DCIS lesions on dynamic bMRI using manual ROI placement with computer-aided analysis and to evaluate whether the latter might increase the detection rate of kinetic features suspicious for malignancy. Material and Methods: The enhancement patterns of 47 histopathologically verified pure DCIS lesions were evaluated on bMRI images using manual ROI placement as well as a commercially available computer analysis software. The latter is able to automatically assess enhancement characteristics of a whole lesion pixelwise. Kinetic features evaluated included classification of lesion enhancement pattern into washout, plateau or persistent curve type. A washout and plateau enhancement pattern are regarded as suggestive for malignancy. Results: Morphological classification revealed focus-like enhancement in 2 lesions, mass enhancement in 11, and non-mass enhancement in 34. Manual placement of ROI demonstrated a suspicious enhancement pattern in 51.1% of the DCIS lesions, which could not be significantly increased using computer-aided analysis. Of the mass and non-mass-enhancing DCIS lesions, 90.9% and 38.3%, respectively, demonstrated suspicious kinetic curves. After application of the automated analysis software, the detection rate of suspicious enhancement patterns was unchanged in mass DCIS lesions and increased to 52.9% in non-mass DCIS lesions ( P=0.33). However, the increase in the detection of washout curves alone was significant ( P=0.02). In all, 40% of G1, 41.1% of G2, and 60% of G3 lesions demonstrated a suspicious curve type with manual evaluation. Computer analysis ...
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Kinetic characteristics of ductal carcinoma in situ (DCIS) in dynamic breast MRI using computer-assisted analysis
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Autor/in / Beteiligte Person: | Vag, Tibor ; Baltzer, Pascal A. T. ; Dietzel, Matthias ; Benndorf, Matthias ; Gajda, Mieczyslaw ; Camara, Oumar ; Kaiser, Werner A. |
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Zeitschrift: | Acta Radiologica, Jg. 51 (2010), Heft 9, S. 955-961 |
Veröffentlichung: | SAGE Publications, 2010 |
Medientyp: | academicJournal |
ISSN: | 0284-1851 |
DOI: | 10.3109/02841851.2010.508171 |
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