ATP2B4 regulatory genetic variants are associated with mild malaria
In: ISSN: 1475-2875 ; Malaria Journal ; https://amu.hal.science/hal-04006760 ; Malaria Journal, 2023, 22 (68), ⟨10.1186/s12936-023-04503-8⟩, 2023
Online
academicJournal
Zugriff:
International audience ; Genome-wide association studies have identified ATP2B4 as a severe malaria resistance gene. Recently, 8 potential causal regulatory variants have been shown to be associated with severe malaria. Methods Genotyping of rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452 was performed in 154 unrelated individuals (79 controls and 75 mild malaria patients). rs10751450, rs10751451 and rs10751452 were genotyped by Taqman assays, whereas the fragment of the ATP2B4 gene containing the remaining SNPs was sequenced. Logistic regression analysis was used to assess the association between the SNPs and mild malaria. Results The results showed that mild malaria was associated with rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452. The homozygous genotypes for the major alleles were associated with an increased risk of mild malaria. Furthermore, the haplotype containing the major alleles and that containing the minor alleles were the most frequent haplotypes. Individuals with the major haplotypes had a significantly higher risk of mild malaria compared to the carriers of the minor allele haplotype. Conclusions ATP2B4 polymorphisms that have been associated with severe malaria are also associated with mild malaria.
Titel: |
ATP2B4 regulatory genetic variants are associated with mild malaria
|
---|---|
Autor/in / Beteiligte Person: | Thiam, Alassane ; Nisar, Samia ; Adjemout, Mathieu ; Gallardo, Frederic ; Ka, Oumar ; Mbengue, Babacar ; Diop, Gora ; Dieye, Alioune ; Marquet, Sandrine ; Rihet, Pascal ; Institut Pasteur de Dakar ; Réseau International des Instituts Pasteur (RIIP) ; Institut Marseille Maladies Rares (MarMaRa) ; Aix Marseille Université (AMU) ; Theories and Approaches of Genomic Complexity (TAGC) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Université Cheikh Anta Diop de Dakar Sénégal (UCAD) |
Link: | |
Zeitschrift: | ISSN: 1475-2875 ; Malaria Journal ; https://amu.hal.science/hal-04006760 ; Malaria Journal, 2023, 22 (68), ⟨10.1186/s12936-023-04503-8⟩, 2023 |
Veröffentlichung: | HAL CCSD ; BioMed Central, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1186/s12936-023-04503-8 |
Schlagwort: |
|
Sonstiges: |
|