Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders
In: ISSN: 0022-1899, 2017
Online
academicJournal
Zugriff:
International audience ; Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcrip-tomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases , ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders.
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Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders
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| Autor/in / Beteiligte Person: | Cabantous, Sandrine ; Doumbo, Ogobara ; Poudiougou, Belco ; Louis, Laurence ; Barry, Abdoulaye ; Oumar, Aboubacar ; Traore, Abdoualye ; Marquet, S. ; Dessein, Alain ; Génétique et immunologie des maladies parasitaires (GIMP) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Department of Epidemiology of Parasitic Disease Bamako, Mali (Faculty of Medicine) ; Université des Sciences, des Techniques et des Technologies de Bamako (USTTB)-Malaria Research and Training Center - MRTC Bamako, Mali ; Génétique Médicale et Génomique Fonctionnelle (GMGF) ; Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone CHU - APHM (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Pediatric Wards Bamako, Mali ; Gabriel Toure Hospital Bamako, Mali ; Centre des Oeuvres Universitaires Bamako, Mali ; University of Bamako Mali ; ANR-11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011) ; European Project: IC18CT980373 |
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| Zeitschrift: | ISSN: 0022-1899, 2017 |
| Veröffentlichung: | HAL CCSD ; Oxford University Press (OUP), 2017 |
| Medientyp: | academicJournal |
| DOI: | 10.1093/infdis/jix359 |
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