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Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from 2021–2022 in four locations in southern Nigeria with reported cases of Lassa fever (LF). Birds, lizards, and domestic mammals (dogs, pigs, cattle and goats) were screened using RT-qPCR, and whole genome sequencing was performed for lineage identification on selected LASV positive samples. Animals were also screened for exposure to LASV by enzyme-linked immunosorbent assay (ELISA). Among these animals, lizards had the highest positivity rate by PCR. Genomic sequencing of samples in most infected animals showed sub-lineage 2 g of LASV. Seropositivity was highest among cattle and lowest in pigs. Though the specific impact these additional hosts may have in the ...

Titel:	Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria ...
Autor/in / Beteiligte Person:	Happi, Anise Nkenjop ; Ogunsanya, Olusola Akinola ; Ayinla, Akeemat Opeyemi ; Sijuwola, Ayotunde Elijah ; Saibu, Femi Mudasiru ; Akano, Kazeem ; Nwofoke, Cecilia ; Elias, Obineche Tobias ; Achonduh-Atijegbe, Olivia ; Daodu, Richard Olumide ; Adedokun, Oluwatobi Abel ; Adeyemo, Abraham ; Ogundana, Kehinde Ebenezer ; Lawal, Omolola Zaheedat ; Parker, Edyth ; Nosamiefan, Iguosadolo ; Okolie, Johnson ; Parker, Zahra F. ; McCauley, Melanie D. ; Eller, Leigh Anne ; Lombardi, Kara ; Tiamiyu, Abdulwasiu Bolaji ; Iroezindu, Michael ; Akinwale, Edward ; Njatou, Thierry Lamare Fouapon Assedi ; Mebrahtu, Tsedal ; Broach, Erica ; Zuppe, Anastasia ; Prins, Petra ; Lay, Jenny ; Amare, Mihret ; Modjarrad, Kayvon ; Collins, Natalie D. ; Vasan, Sandhya ; Tucker, Cynthia ; Daye, Sharon ; Happi, Christian Tientcha
Link:	https://doi.org/10.1080/22221751.2023.2294859 https://doi.org/10.6084/m9.figshare.2504392410.1080/22221751.2023.2294859 https://tandf.figshare.com/articles/journal_contribution/Lassa_virus_in_novel_hosts_insights_into_the_epidemiology_of_lassa_virus_infections_in_southern_Nigeria/25043924
Veröffentlichung:	Taylor & Francis, 2024
Medientyp:	academicJournal
DOI:	10.6084/m9.figshare.25043924
Schlagwort:	Medicine Microbiology FOS Biological sciences Biotechnology Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Immunology FOS Clinical medicine Biological Sciences not elsewhere classified Cancer Infectious Diseases FOS Health sciences Virology
Sonstiges:	Nachgewiesen in: BASE Sprachen: unknown Collection: DataCite Metadata Store (German National Library of Science and Technology) Document Type: text ; other non-article part of journal/newspaper Language: unknown Rights: Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0

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Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria ...