Mitochondrial formation of hydrogen peroxide is causally linked to the antimycin A‐mediated prevention of tert ‐butylhydroperoxide‐induced U937 cell death
In: FEBS Letters, Jg. 431 (1998), Heft 2, S. 245-249
academicJournal
Zugriff:
Antimycin A and 2‐heptyl‐4‐hydroxyquinoline N‐oxide (HQNO), both of which bind to the same site of complex III, prevented U937 cell killing promoted by tert ‐butylhydroperoxide (tB‐OOH). This cytoprotection was not directly caused by inhibition of electron transport or reduced formation of tB‐OOH‐derived toxic species, but rather appeared to be the consequence of a mechanism involving mitochondrial formation of hydrogen peroxide. Ubisemiquinone was most likely the electron donor allowing the formation of superoxides and, as a consequence, of hydrogen peroxide.
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Mitochondrial formation of hydrogen peroxide is causally linked to the antimycin A‐mediated prevention of tert ‐butylhydroperoxide‐induced U937 cell death
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Autor/in / Beteiligte Person: | Brambilla, Liliana ; Cantoni, Orazio |
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Zeitschrift: | FEBS Letters, Jg. 431 (1998), Heft 2, S. 245-249 |
Veröffentlichung: | Wiley, 1998 |
Medientyp: | academicJournal |
ISSN: | 0014-5793 |
DOI: | 10.1016/s0014-5793(98)00764-9 |
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