Factors Associated with Prevalent Mycobacterium Tuberculosis Infection and Disease Among Adolescents and Adults Exposed to Rifampin-Resistant Tuberculosis in the Household
In: Journal Articles: Infectious Diseases, 2023
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Zugriff:
BACKGROUND: Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. METHODS: Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations. RESULTS: Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25-49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status. Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment. CONCLUSION: We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis ...
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Factors Associated with Prevalent Mycobacterium Tuberculosis Infection and Disease Among Adolescents and Adults Exposed to Rifampin-Resistant Tuberculosis in the Household
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Autor/in / Beteiligte Person: | Kim, Soyeon ; Hesseling, Anneke C. ; Wu, Xingye ; Hughes, Michael D. ; Shah, N. Sarita ; Gaikwad, Sanjay ; Kumarasamy, Nishi ; Mitchell, Erika ; Leon, Mey ; Gonzales, Pedro ; Badal-Faesen, Sharlaa ; Lourens, Madeleine ; Nerette, Sandy ; Shenje, Justin ; de Koker, Petra ; Nedsuwan, Supalert ; Mohapi, Lerato ; Chakalisa, Unoda A. ; Mngqbisa, Rosie ; Escada, Rodrigo Otávio da Silva ; Ouma, Samuel ; Heckman, Barbara ; Naini, Linda ; Gupta, Amita ; Swindells, Susan ; Churchyard, Gavin ; ACTG A5300/IMPAACT 2003 PHOENIx Feasibility Study Team |
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Zeitschrift: | Journal Articles: Infectious Diseases, 2023 |
Veröffentlichung: | DigitalCommons@UNMC, 2023 |
Medientyp: | academicJournal |
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