Evaluation of response strategies against epidemics due to Neisseria meningitidis C in Niger
In: ISSN: 1360-2276, 2017
Online
academicJournal
Zugriff:
International audience ; OBJECTIVE: To inform public health recommendations, we evaluated the effectiveness and efficiency of current and hypothetical surveillance and vaccine response strategies against Neisseria meningitidis C meningitis epidemics in 2015 in Niger.METHODS : We analysed reports of suspected and confirmed cases of meningitis from the region of Dosso during 2014 and 2015. Based on a definition of epidemic signals, the effectiveness and efficiency of surveillance and vaccine response strategies were evaluated by calculating the number of potentially vaccine-preventable cases and number of vaccine doses needed per epidemic signal.RESULTS : A total of 4763 weekly health area reports, collected in 90 health areas with 1282 suspected meningitis cases, were included. At a threshold of 10 per 100 000, the total number of estimated vaccine-preventable cases was 29 with district-level surveillance and vaccine response, 141 with health area-level surveillance and vaccination and 339 with health area-level surveillance and district-level vaccination. While being most effective, the latter strategy required the largest number of vaccine doses (1.8 million), similar to the strategy of surveillance and vaccination at district level (1.3 million), whereas the strategy of surveillance and vaccination at health area level would have required only 0.8 million doses. Thus, efficiency was lowest for district-level surveillance and highest for health area-level surveillance with district-level vaccination.CONCLUSION : In this analysis, we found that effectiveness and efficiency were higher at health area-level surveillance and district-level vaccination than for other strategies. Use of N. meningitidis C vaccines in a preventive strategy thus should be considered, in particular as most reactive vaccine response strategies in our analysis had little impact on disease burden.
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Evaluation of response strategies against epidemics due to Neisseria meningitidis C in Niger
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Autor/in / Beteiligte Person: | Maïnassara, Halima Boubacar ; Oumarou, Garba Idé ; Issaka, Bassira ; Sidiki, Ali ; Idi, Issa ; Pelat, Jean-Paul Moulia ; Fontanet, Arnaud ; Mueller, Judith E. ; Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES) ; Réseau International des Instituts Pasteur (RIIP) ; Département Infection et Epidémiologie - Department of Infection and Epidemiology ; Institut Pasteur Paris (IP) ; Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM) ; Cellule Pasteur, UPMC ; Institut Pasteur Paris (IP)-Sorbonne Université (SU) ; École des Hautes Études en Santé Publique EHESP (EHESP) ; Département Méthodes quantitatives en santé publique (METIS) ; Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology ; Pasteur-Cnam Risques infectieux et émergents (PACRI) ; Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM) ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM) ; This work was supported by the CDC/MenAfriNet and the Office of International Cooperation of the Principality of Monaco. Surveillance activities were funded by the Ministère Français des Affaires Etrangères (Fonds de Solidarité Prioritaire), Sanofi Pasteur and the ‘Ministère de la Santé Publique du Niger/Fonds commun’. The ‘Cooperation Technique Belge’ funded the first health area map's support. ; We acknowledge the contribution of all the staff of the ‘Centre de RechercheMédicale et Sanitaire’ and health centres of Niger who participated in the meningitis surveillance, the ‘Direction de la Surveillance et de la Riposte aux Epidémies’, the ‘Direction des Statistiques’, the ‘Institut National de la Statistique’, the World Health Organization, the CDC/MenAfriNet and the United Nations International Children's Emergency Fund. ; internationale, Collaboration |
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Zeitschrift: | ISSN: 1360-2276, 2017 |
Veröffentlichung: | HAL CCSD ; Wiley-Blackwell, 2017 |
Medientyp: | academicJournal |
DOI: | 10.1111/tmi.12815 |
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