Chemical modification of the adeno-associated virus capsid to improve gene delivery
In: Chemical Science, Jg. 11 (2020), Heft 4, S. 1122-1131
Online
academicJournal
Zugriff:
Bioconjugated AAV vectors, achieved by coupling of ligands on amino groups of the capsid, are of great interest for gene delivery. Chemical modifications can be used to enhance cell tropism and to decrease interactions with neutralizing antibodies.
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Chemical modification of the adeno-associated virus capsid to improve gene delivery
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Autor/in / Beteiligte Person: | Mével, Mathieu ; Bouzelha, Mohammed ; Leray, Aurélien ; Pacouret, Simon ; Guilbaud, Mickael ; Penaud-Budloo, Magalie ; Alvarez-Dorta, Dimitri ; Dubreil, Laurence ; Gouin, Sébastien G. ; Combal, Jean Philippe ; Hommel, Mirja ; Gonzalez-Aseguinolaza, Gloria ; Blouin, Véronique ; Moullier, Philippe ; Adjali, Oumeya ; Deniaud, David ; Ayuso, Eduard ; Institut National de la Santé et de la Recherche Médicale ; Université de Nantes ; Centre Hospitalier Universitaire de Nantes ; Agence Nationale de la Recherche |
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Zeitschrift: | Chemical Science, Jg. 11 (2020), Heft 4, S. 1122-1131 |
Veröffentlichung: | Royal Society of Chemistry (RSC), 2020 |
Medientyp: | academicJournal |
ISSN: | 2041-6520 |
DOI: | 10.1039/c9sc04189c |
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