Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso
In: ISSN: 1999-4915 ; Viruses ; https://hal.umontpellier.fr/hal-02418336 ; Viruses, 2019, 11 (6), pp.554. ⟨10.3390/v11060554⟩, 2019
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International audience ; Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.
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Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso
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| Autor/in / Beteiligte Person: | Dimeglio, Chloé ; Kania, Dramane ; Mantono, Judith Mbombi ; Kagoné, Thérèse ; Zida, Sylvie ; Tassembedo, Souleymane ; Dicko, Amadou ; Tinto, Bachirou ; Yaro, Seydou ; Hien, Hervé ; Rouamba, Jérémi ; Bicaba, Brice ; Medah, Isaïe ; Meda, Nicolas ; Traoré, Oumar ; Tuaillon, Edouard ; Legrand-Abravanel, Florence ; Izopet, Jacques ; Laboratoire Virologie CHU Toulouse ; Institut Fédératif de Biologie (IFB) ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie CHU Toulouse ; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) ; Centre Muraz Bobo-Dioulasso, Burkina Faso ; Université Catholique de l'Afrique de l'Ouest (UCAO) ; Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz ; Université Joseph Ki-Zerbo Université de Ouagadougou, Burkina Faso (UJZK) ; Ministère de la Santé Burkina Faso ; Agence nationale de biosécurité ; Pathogénèse et contrôle des infections chroniques (PCCI) ; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) ; Etablissement français du don du sang Montpellier ; Centre de Physiopathologie Toulouse Purpan (CPTP) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
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| Zeitschrift: | ISSN: 1999-4915 ; Viruses ; https://hal.umontpellier.fr/hal-02418336 ; Viruses, 2019, 11 (6), pp.554. ⟨10.3390/v11060554⟩, 2019 |
| Veröffentlichung: | HAL CCSD ; MDPI, 2019 |
| Medientyp: | academicJournal |
| DOI: | 10.3390/v11060554 |
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