Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial.
In: ISSN: 1042-8194, 2012
academicJournal
Zugriff:
International audience ; Infections are a major complication in patients with acute myeloid leukemia undergoing intensive chemotherapy. They remain a major cause of therapy-associated morbidity and mortality, and represent a frequent cause of treatment withdrawal. An analysis of the medical charts of 459 younger adults included in the multicenter Acute Leukemia French Association (ALFA)-9802 trial showed that 1369 febrile episodes occurred among the 459 registered patients, including fever without identifiable source (23%) and clinically or microbiologically documented infections (77%). Bloodstream infections occurred in 314 episodes, including 129 documented episodes with Gram-positive and 96 with Gram-negative pathogens. Pulmonary infection was diagnosed in 144/1054 documented infectious episodes (14%). Invasive fungal infection was probable or proven in 116 patients. In all, 15 patients died of infection-associated complications, of whom seven died during early induction therapy, one during salvage therapy and seven during consolidation therapy. Better supportive care strategies may improve overall survival in patients undergoing chemotherapy for acute myeloid leukemia.
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Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial.
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Autor/in / Beteiligte Person: | Cannas, Giovanna ; Pautas, Cécile ; Raffoux, Emmanuel ; Quesnel, Bruno ; de Botton, Stéphane ; de Revel, Thierry ; Reman, Oumedaly ; Gardin, Claude ; Elhamri, Mohamed ; Boissel, Nicolas ; Fenaux, Pierre ; Michallet, Mauricette ; Castaigne, Sylvie ; Dombret, Hervé ; Thomas, Xavier ; Hôpital Edouard Herriot CHU -, HCL ; Hospices Civils de Lyon (HCL) ; Service d'hématologie clinique ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) ; Hopital Saint-Louis AP-HP (AP-HP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc) ; Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille ; hopital des armées percy ; Département d' Hématologie ; hopital georges clémenceau ; Service d'hématologie clinique Avicenne ; Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne AP-HP ; Service d'hématologie Hôpital Edouard Herriot -, HCL ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) ; Centre Hospitalier de Versailles André Mignot (CHV) ; Lymphocyte et cancer ; IFR105-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL) ; Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 1042-8194, 2012 |
Veröffentlichung: | HAL CCSD ; Taylor & Francis, 2012 |
Medientyp: | academicJournal |
DOI: | 10.3109/10428194.2011.636812 |
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