Cytotoxic constituents from the fruit of Solanum aculeastrum ...
Taylor & Francis, 2024
academicJournal
Zugriff:
A new triterpene, aculeastrumone A ( 1 ), a new triterpene saponin aculeastrumoside A ( 2 ), and eleven known compounds ( 3–13 ) were isolated from MeOH/Water (80/20) extract of the fruits of Solanum aculeastrum (Solanaceae). Their structures were established by detailed 1D and 2D NMR spectroscopic studies and mass spectrometry. The isolated compounds were evaluated against three human cancer cells ((MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer)) and normal human fibroblast (BJ) cell lines. Among them, saponins 2–5, 7–8 , and Carpesterol 10 possess significant cytotoxic activity with IC 50 ≤ 10 µM against the three cancer cell lines. ...
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Cytotoxic constituents from the fruit of Solanum aculeastrum ...
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Autor/in / Beteiligte Person: | Tchapnda, Nadine-Phalone Tinguep ; Njambouo, Ruth Bibiane Njinkou ; Kenmogne, Marguerite Hortence Tchuendem ; Douanla, Pascal Djimeli ; Shiono, Yoshihito ; Tabopda, Turibio Kuiate |
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Veröffentlichung: | Taylor & Francis, 2024 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.25294904.v1 |
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