Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
In: European Journal of Medical Research, Vol 14, Iss 7, Jg. 14 (2009), Heft 7, p 315
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Zugriff:
Statement of the problem Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results Oral ASD foci consisting of CD31-and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p < 0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p < 0.05). Conclusions These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index.
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Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions
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Autor/in / Beteiligte Person: | Siar, CH ; Oo, VPA ; Nagatsuka, H ; Nakano, K ; Ng, KH ; Kawakami, T |
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Zeitschrift: | European Journal of Medical Research, Vol 14, Iss 7, Jg. 14 (2009), Heft 7, p 315 |
Veröffentlichung: | BMC, 2009 |
Medientyp: | academicJournal |
ISSN: | 2047-783X (print) |
DOI: | 10.1186/2047-783X-14-7-315 |
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