Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract
In: ISSN: 1475-2875 ; Malaria Journal ; https://hal.science/hal-01979829 ; Malaria Journal, 2017, 16 (1), pp.409. ⟨10.1186/s12936-017-2052-0⟩, 2017
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International audience ; BACKGROUND: Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversion rates and entomological inoculation rates (EIR). However, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. This study monitors the use of antibody responses to P. falciparum crude extracts for assessing malaria transmission, compares seroconversion rates estimated from longitudinal data to those derived from cross-sectional surveys and investigates the effects of malaria control interventions on these measures in an area of declining malaria transmission. In addition, the validity of this model was evaluated by comparison with the alternative model.METHODS: Five cross-sectional surveys were carried out at the end of the wet season in Dielmo, a malaria-endemic Senegalese rural area in 2000, 2002, 2008, 2010 and 2012. Antibodies against schizonts crude extract of a local P. falciparum strain adapted to culture (Pf 07/03) were measured by ELISA. Age-specific seroprevalence model was used both for cross-sectional surveys and longitudinal data (combined data of all surveys).RESULTS: A total of 1504 plasma samples obtained through several years follow-up of 350 subjects was used in this study. Seroconversion rates based on P. falciparum schizonts crude extract were estimated for each cross-sectional survey and were found strongly correlated with EIR. High variability between SCRs from cross-sectional and longitudinal surveys was observed. In longitudinal studies, the alternative catalytic reversible model adjusted better with serological data than the catalytic model. Clinical malaria attacks and malaria control interventions were found to have significant effect on seroconversion.DISCUSSION: The results of the study suggested ...
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Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract
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Autor/in / Beteiligte Person: | Niass, Oumy ; Saint-Pierre, Philippe ; Niang, Makhtar ; Diop, Fode ; Diouf, Babacar ; Faye, Michel Matar ; Sarr, Fatoumata Diene ; Faye, Joseph ; Diagne, Nafissatou ; Sokhna, Cheikh ; Trape, Jean-Francois ; Perraut, Ronald ; Tall, Adama ; Diongue, Abdou Kâ ; Toure Balde, Aïssatou ; Institut Pasteur de Dakar ; Réseau International des Instituts Pasteur (RIIP) ; Université Gaston Berger de Saint-Louis Sénégal (UGB) ; Institut de Mathématiques de Toulouse UMR5219 (IMT) ; Université Toulouse Capitole (UT Capitole) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse) ; Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J) ; Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) ; Institut de recherche pour le développement Dakar, Sénégal (IRD Hann Maristes) ; Institut de recherche pour le développement (IRD Sénégal ) ; the authors thank the CEA-MITIC and the SCAC embassy of French for their grant. ; The authors express their gratitude to the population of Dielmo and Ndiop for their participation in the study. The healthcare workers in Dielmo and Ndiop are dully acknowledged for their cooperation in conducting this study |
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Zeitschrift: | ISSN: 1475-2875 ; Malaria Journal ; https://hal.science/hal-01979829 ; Malaria Journal, 2017, 16 (1), pp.409. ⟨10.1186/s12936-017-2052-0⟩, 2017 |
Veröffentlichung: | HAL CCSD ; BioMed Central, 2017 |
Medientyp: | academicJournal |
DOI: | 10.1186/s12936-017-2052-0 |
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