ΒΙΟΛΟΓΙΚΟΣ ΡΟΛΟΣ ΚΑΙ ΡΥΘΜΙΣΤΙΚΟΙ ΠΑΡΑΓΟΝΤΕΣ ΤΗΣ ΕΠΑΓΩΓΗΣ ΤΗΣ ΑΛΔΕΥΔΙΚΗΣ ΑΦΥΔΡΟΓΟΝΑΣΗΣ - 3 ; BIOLOGICAL ROLE AND REGULATORY FACTORS OF THE INDUCTION OF ALDEΗYDE DEHYDROGENASE - 3

THE CYTOSOLIC CLASS 3 ALDEHYDE DEHYDROGENASE (ALDH3C) CATALYZES THE OXIDATION OF ALDEHYDES TO THE CORRESPONDING CARBOΧYLIC ACIDS, AND IS GREATLY INDUCED BY POLYCYCLIC AROMATIC HYDROCARBONS (PAHS), IN MANY TISSUES IN VARIOUS MAMMALS AND OTHER SPECIES. IN THE PRESENT STUDY, WE EXAMINED THE BIOLOGICAL ROLE OF THE ALDH3C INDUCTION, AS WELL AS REGULATORY FACTORS OF THE INDUCTION OF ALDH3C BY PAHS, IN THE RAT LIVER. THE RESULTS OF ADMINISTRATION OF SPECIFIC DEPLETORS AND/OR PERCURSORS OF GLUTATHIONE TO THE RATS SHOWN THAT THE PHYSIOLOGICAL LEVELS OF GLUTATHIONE ARE IMPORTANT FACTOR IN THE PROCESS OF ALDH3C INDUCTION.NON - STEROIDAL AND/OR STEROIDAL ANTI - INFLAMMATORY DRUG - TREATMENT OF THE ALDH3C INDUCTION RESULTED THE REGULATORY EFFECTS OF THE INFLAMMATORY PRODUCTS OF ARACHIDONIC ACID CASCADE, ON THE ALDH3C INDUCTION. FINALLY, THE INDUCTION OF ALDH3C STUDIED IN EXTAHEPATIC WISTAR RAT TISSUES WITH SPECIAL FUNCTIONALITY, AS FAR AS THE RESPONSE TO OXIDATIVE STRESS IS CONCERNED. IN CONLUSION, THESE RESULTS PROVIDE MORE EVIDENCE ABOUT THE ROLE OF ALDH3C WHICH METABOLIZE ALDEHYDIC PRODUCTS OF OXIDATIVE STRESS. ACCORDING TO THE RESULTS OF THE PRESENT STUDY, THE INDUCTION OF ALDH3C ACTIVITY CAN BE RELATED WITH A CHEMICALLY- PRODUCED ASEPTIC CELL INFLAMMATION. ITS ACTION CORRELATED WITH PROSTAGLANDIN AVAILABILITY, THE METABOLISM AS WELL AS THE DETOXIFICATION OF WHICH, IS CONCERNED AS A POSSIBLE ROLE FOR THE ALDH3C. ; Η ΚΥΤΤΑΡΟΠΛΑΣΜΑΤΙΚΗ ΑΛΔΕΥΔΙΚΗ ΑΦΥΔΡΟΓΟΝΑΣΗ - 3 (ALDH3C), ΠΟΥ ΚΑΤΑΛΥΕΙ ΤΗΝ ΑΝΤΙΔΡΑΣΗ ΟΞΕΙΔΩΣΗΣ ΑΛΔΕΥΔΩΝ ΣΤΑ ΑΝΤΙΣΤΟΙΧΑ ΚΑΡΒΟΞΥΛΙΚΑ ΟΞΕΑ, ΕΠΑΓΕΤΑΙ ΣΕ ΕΝΤΥΠΩΣΙΑΚΟ ΒΑΘΜΟ, ΣΕ ΠΟΛΛΟΥΣ ΙΣΤΟΥΣ, ΥΣΤΕΡΑ ΑΠΟ ΧΟΡΗΓΗΣΗ ΠΟΛΥΚΥΚΛΙΚΩΝ ΑΡΩΜΑΤΙΚΩΝ ΥΔΡΟΓΟΝΑΝΘΡΑΚΩΝ (ΠΑΥ). ΣΤΗΝ ΠΑΡΟΥΣΑ ΜΕΛΕΤΗ ΔΙΕΡΕΥΝΗΘΗΚΕ Ο ΒΙΟΛΟΓΙΚΟΣ ΡΟΛΟΣ ΤΗΣ ΕΠΑΓΜΕΝΗΣ ALDH3C ΚΑΙ ΕΞΕΤΑΣΤΗΚΑΝ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΕΠΗΡΕΑΖΟΥΝ ΤΗΝ ΕΠΑΓΩΓΗ ΤΗΣ ALDH3C ΑΠΟ ΠΑΥ. Η ΧΡΗΣΙΜΟΠΟΙΗΣΗ ΕΙΔΙΚΩΝ ΟΥΣΙΩΝ ΠΟΥ ΜΕΙΩΝΟΥΝ Η ΑΥΞΑΝΟΥΝ ΤΑ ΕΝΔΟΓΕΝΗΑΠΟΘΕΜΑΤΑ ΓΛΟΥΤΑΘΕΙΟΝΗΣ ΕΔΕΙΞΕ ΟΤΙ ΤΑ ΦΥΣΙΟΛΟΓΙΚΑ ΕΠΙΠΕΔΑ ΓΛΟΥΤΑΘΕΙΟΝΗΣ ΕΙΝΑΙ ΣΗΜΑΝΤΙΚΟΣ ΠΑΡΑΓΟΝΤΑΣ ΣΤΗΝ ΠΟΡΕΙΑ ΕΠΑΓΩΓΗΣ ΤΗΣ ALDH3C. ΕΠΙΣΗΣ, Η ΧΟΡΗΓΗΣΗ ...