Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study
In: Anaesthesia, vol 76, iss 6, 2021
academicJournal
Zugriff:
Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2weeks, 3-4weeks and 5-6weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥7weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥7week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥7weeks from diagnosis may benefit from further delay.
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Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study
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Autor/in / Beteiligte Person: | Nepogodiev, Dmitri ; Simoes, Joana FF ; Li, Elizabeth ; Picciochi, Maria ; Glasbey, James C ; Baiocchi, Glauco ; Blanco‐Colino, Ruth ; Chaudhry, Daoud ; AlAmeer, Ehab ; El‐Boghdadly, Kariem ; Wuraola, Funmilola ; Ghosh, Dhruva ; Gujjuri, Rohan R ; Harrison, Ewen M ; Lule, Herman ; Kaafarani, Haytham ; Khosravi, Mohammad ; Kronberger, Irmgard ; Leventoğlu, Sezai ; Mann, Harvinder ; Mclean, Kenneth A ; Mengesha, Mengistu Gebreyohanes ; Modolo, Maria Marta ; Ntirenganya, Faustin ; Norman, Lisa ; Outani, Oumaima ; Pius, Riinu ; Pockney, Peter ; Qureshi, Ahmad Uzair ; Roslani, April Camilla ; Satoi, Sohei ; Shaw, Catherine ; Bhangu, Aneel ; Omar, Omar M ; Ahmed, Waheed‐Ul‐Rahman ; Argus, Leah ; Ball, Alasdair ; Bywater, Edward P ; Brar, Amanpreet ; Dawson, Brett E ; Duran, Irani ; Elhadi, Muhammed ; Jones, Conor S ; Kamarajah, Sivesh K ; Keatley, James M ; Lawday, Samuel ; Marson, Ella J ; Ots, Riinu ; Santos, Irène ; Taylor, Elliott H ; Trout, Isobel M ; Varghese, Chris ; Venn, Mary L ; Xu, William ; Dajti, Irida ; Gjata, Arben ; Kacimi, Salah Eddine Oussama ; Boccalatte, Luis ; Cox, Daniel ; Townend, Philip ; Aigner, Felix ; Kronberger, Irmgard Elisabeth ; Samadov, Elgun ; Alderazi, Amer ; Hossain, Kamral ; Padmore, Greg ; van Ramshorst, Gabrielle ; Lawani, Ismaïl ; Cerovac, Anis ; Delibegovic, Samir ; Gomes, Gustavo Mendonça Ataíde ; Buarque, Igor Lima ; Gohar, Muhammad ; Slavchev, Mihail ; Nwegbu, Chukwuemeka ; Agarwal, Arnav ; Martin, Janet ; Ng‐Kamstra, Joshua |
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Zeitschrift: | Anaesthesia, vol 76, iss 6, 2021 |
Veröffentlichung: | eScholarship, University of California, 2021 |
Medientyp: | academicJournal |
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