Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries
In: 10.1371/journal.pntd.0004019 ; oai:pubmedcentral.nih.gov:4607489 ; oai:nhm.openrepository.com:10141/614585 ; oai:doaj.org/article:7ea824555854403daaf9491653871759 ; oai:spiral.imperial.ac.uk:10044/1/26974 ; 2135078071 ; oai:researchonline.rvc.ac.uk:9437 ; 26469347 ; 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 ; 10|openaire____::55045bd2a65019fd8e6741a755395c8c ; 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357 ; 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c ; 10|opendoar____::69f357fcc8e6d119f3d95f33cedb5915 ; 10|driver______::bee53aa31dc2cbb538c10c2b65fa5824 ; 10|doajarticles::20b0e9f3c7e4e7612c72a1621493101d ; 10|opendoar____::995e1fda4a2b5f55ef0df50868bf2a8f ; 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 ; 10|openaire____::8ac8380272269217cb09a928c8caa993 ; 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a ; 10|openaire____::0a836ef43dcb67bb7cbd4dd509b11b73, 2015
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Zugriff:
Background In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood. Methodology/Principal Findings Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined. Conclusions/Significance These findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could ...
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Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries
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Autor/in / Beteiligte Person: | Knowles, Sarah C. L. ; Webster, Bonnie L. ; Sacko, Moussa ; Garba, Amadou ; Diaw, Oumar T. ; Webster, Joanne P. ; Fenwick, Alan ; Rollinson, David ; Raso, Giovanna ; Raso, G |
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Zeitschrift: | 10.1371/journal.pntd.0004019 ; oai:pubmedcentral.nih.gov:4607489 ; oai:nhm.openrepository.com:10141/614585 ; oai:doaj.org/article:7ea824555854403daaf9491653871759 ; oai:spiral.imperial.ac.uk:10044/1/26974 ; 2135078071 ; oai:researchonline.rvc.ac.uk:9437 ; 26469347 ; 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 ; 10|openaire____::55045bd2a65019fd8e6741a755395c8c ; 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357 ; 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c ; 10|opendoar____::69f357fcc8e6d119f3d95f33cedb5915 ; 10|driver______::bee53aa31dc2cbb538c10c2b65fa5824 ; 10|doajarticles::20b0e9f3c7e4e7612c72a1621493101d ; 10|opendoar____::995e1fda4a2b5f55ef0df50868bf2a8f ; 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 ; 10|openaire____::8ac8380272269217cb09a928c8caa993 ; 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a ; 10|openaire____::0a836ef43dcb67bb7cbd4dd509b11b73, 2015 |
Veröffentlichung: | Public Library of Science (PLoS) ; Figshare, 2015 |
Medientyp: | academicJournal |
DOI: | 10.1371/journal.pntd.0004019 |
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