Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs
In: ISSN: 0927-7765 ; EISSN: 1873-4367, 2020
Online
academicJournal
Zugriff:
International audience ; The purpose of this study was to develop Pickering water-in-oil nano-emulsions only stabilized by Eudragit RL100 nanoparticles (NPs), in order to increase the nano-emulsion stability and create a barrier to improve the drug encapsulation and better control the drug release. The first part of this study was dedicated to investigating the nano-emulsion formulation by ultrasonication and understanding the interfacial behavior and role of NPs in the stabilization of the water/oil interface. The focus was on the surface coverage in the function of the formulation parameters (volume fractions) to disclose the extents and limitations of the process. The main physicochemical analysis of the Pickering nano-emulsions was performed by dynamic light scattering and transmission electron microscopy. On the other hand, the second experimental approach was dedicated to understanding the interfacial behavior of the Eudragit RL100 NPs toward a model water/oil interface, using a dynamic tensiometer with axisymmetric drop shape analysis. The study investigated the NPs’ adsorption, as well as their rheological behavior. The aim of this part was to reveal the main phenomena that govern the interactions between NPs and the interface in order to understand the origin of Pickering nano-emulsions’ stability. The last part of the study was concerned with the stability and in vitro release of a model encapsulated drug (ketoprofen) in a gastric and simulated intestinal environment. The results showed that Pickering nano-emulsions significantly improved the resistance to gastric pH, inducing a significantly slower drug release compared to classical nano-emulsions’ stabilized surfactants. These Pickering nano-emulsions appear as a promising technology to modify the delivery of a therapeutic agent, in the function of the pH, and can be, for instance, applied to the oral drug delivery of poorly soluble drugs.
| Titel: |
Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs
|
|---|---|
| Autor/in / Beteiligte Person: | Dieng, Sidy Mouhamed ; Omran, Ziad ; Anton, Nicolas ; Thioune, Oumar ; Djiboune, Alphonse Rodrigue ; Sy, Papa Mady ; Messaddeq, Nadia ; Ennahar, Saïd ; Diarra, Mounibé ; Vandamme, Thierry ; Conception et application de molécules bioactives (CAMB) ; Université de Strasbourg (UNISTRA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) ; Umm AlQura University ; Université Cheikh Anta Diop de Dakar Sénégal (UCAD) ; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) ; Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Institut Pluridisciplinaire Hubert Curien (IPHC) ; Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Link: | |
| Zeitschrift: | ISSN: 0927-7765 ; EISSN: 1873-4367, 2020 |
| Veröffentlichung: | HAL CCSD ; Elsevier, 2020 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.colsurfb.2020.111010 |
| Schlagwort: |
|
| Sonstiges: |
|